2(S)-4-Benzoyloxy carbonyl-2-phthalimido butyryl chloride

Base Information

• Chemical Name: 2(S)-4-Benzoyloxy carbonyl-2-phthalimido butyryl chloride
• CAS No.: 88767-16-2
• Molecular Formula: C20H16 Cl N O5
• Molecular Weight: 385.804
• Hs Code.: 2925190090
• Mol file: 88767-16-2.mol

Synonyms:2H-Isoindole-2-butanoicacid, g-(chlorocarbonyl)-1,3-dihydro-1,3-dioxo-,phenylmethyl ester, (S)-

Chemical Property of 2(S)-4-Benzoyloxy carbonyl-2-phthalimido butyryl chloride

Chemical Property:

• PSA: 80.75000
• LogP: 2.87810

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2(S)-4-Benzoyloxy carbonyl-2-phthalimido butyryl chloride

There total 3 articles about 2(S)-4-Benzoyloxy carbonyl-2-phthalimido butyryl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S)-4-benzyloxicarbonyl-2-phthalimidobutanoic acid (88784-33-2) → (S)-4-Chlorocarbonyl-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyric acid benzyl ester (88767-16-2)

Guidance literature:

With thionyl chloride; In toluene;

Reference yield:

L-glutamic acid γ-benzyl ester (1676-73-9,25014-27-1) → (S)-4-Chlorocarbonyl-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyric acid benzyl ester (88767-16-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / TEA / tetrahydrofuran / Heating

2: PCl₅ / CH₂Cl₂

With TEA; phosphorus pentachloride; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0960-894X(99)00236-X

Reference yield:

N-ethoxycarbonylphthalimide (22509-74-6) → (S)-4-Chlorocarbonyl-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyric acid benzyl ester (88767-16-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / TEA / tetrahydrofuran / Heating

2: PCl₅ / CH₂Cl₂

With TEA; phosphorus pentachloride; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0960-894X(99)00236-X

upstream raw materials:

(2S)-4-benzyloxicarbonyl-2-phthalimidobutanoic acid

L-glutamic acid γ-benzyl ester

N-ethoxycarbonylphthalimide

Downstream raw materials:

(S)-2-[(S)-4-Benzyloxycarbonyl-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyryl]-tetrahydro-pyridazine-1,3-dicarboxylic acid 1-benzyl ester 3-tert-butyl ester

(1S,9S)-t-butyl 1,2,3,4,7,8,9,10-octahydro-6,10-dioxo-9-phthalimidopyridazino<1,2-a><1,2>diazepine-1-carboxylate

(1S,9S)-9-Benzoylamino-6,10-dioxo-octahydro-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid

9-benzoylamino-6,10-dioxo-octahydro-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid tert-butyl ester