ethyl (E)-3-[1-methyl-5-(triphenylmethylamino)pyrazol-4-yl]acrylate

Base Information

• Chemical Name: ethyl (E)-3-[1-methyl-5-(triphenylmethylamino)pyrazol-4-yl]acrylate
• CAS No.: 474956-64-4
• Molecular Formula: C₂₈H₂₇N₃O₂
• Molecular Weight: 437.541
• Mol file: 474956-64-4.mol

Synonyms:ethyl (E)-3-[1-methyl-5-(triphenylmethylamino)pyrazol-4-yl]acrylate

Chemical Property of ethyl (E)-3-[1-methyl-5-(triphenylmethylamino)pyrazol-4-yl]acrylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of ethyl (E)-3-[1-methyl-5-(triphenylmethylamino)pyrazol-4-yl]acrylate

There total 1 articles about ethyl (E)-3-[1-methyl-5-(triphenylmethylamino)pyrazol-4-yl]acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

diethoxyphosphoryl-acetic acid ethyl ester (867-13-0) + 1-methyl-5-(tritylamino)pyrazole-4-carbaldehyde (474956-63-3) → ethyl (E)-3-[1-methyl-5-(triphenylmethylamino)pyrazol-4-yl]acrylate (474956-64-4)

Guidance literature:

diethoxyphosphoryl-acetic acid ethyl ester; With sodium hydride; In tetrahydrofuran; for 1h; cooling;

1-methyl-5-(tritylamino)pyrazole-4-carbaldehyde; In tetrahydrofuran; at 20 ℃; for 17h; Further stages.;

DOI:10.1016/j.bmc.2007.11.074

Reference yield: 74.0%

ethyl (E)-3-[1-methyl-5-(triphenylmethylamino)pyrazol-4-yl]acrylate (474956-64-4) → 3-[1-methyl-5-(triphenylmethylamino)pyrazol-4-yl]propanol (474956-65-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1016/j.bmc.2007.11.074

upstream raw materials:

diethoxyphosphoryl-acetic acid ethyl ester

1-methyl-5-(tritylamino)pyrazole-4-carbaldehyde

Downstream raw materials:

3-[1-methyl-5-(triphenylmethylamino)pyrazol-4-yl]propanol