4-Methylene-hexanoic acid {ethoxy-[1-(4-methoxy-benzenesulfonyl)-2-methyl-1H-indol-3-yl]-methyl}-(2-phenylsulfanyl-ethyl)-amide

Base Information

• Chemical Name: 4-Methylene-hexanoic acid {ethoxy-[1-(4-methoxy-benzenesulfonyl)-2-methyl-1H-indol-3-yl]-methyl}-(2-phenylsulfanyl-ethyl)-amide
• CAS No.: 80664-30-8
• Molecular Formula: C₃₄H₄₀N₂O₅S₂
• Molecular Weight: 620.834
• Mol file: 80664-30-8.mol

Synonyms:4-Methylene-hexanoic acid {ethoxy-[1-(4-methoxy-benzenesulfonyl)-2-methyl-1H-indol-3-yl]-methyl}-(2-phenylsulfanyl-ethyl)-amide

Chemical Property of 4-Methylene-hexanoic acid {ethoxy-[1-(4-methoxy-benzenesulfonyl)-2-methyl-1H-indol-3-yl]-methyl}-(2-phenylsulfanyl-ethyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Methylene-hexanoic acid {ethoxy-[1-(4-methoxy-benzenesulfonyl)-2-methyl-1H-indol-3-yl]-methyl}-(2-phenylsulfanyl-ethyl)-amide

There total 7 articles about 4-Methylene-hexanoic acid {ethoxy-[1-(4-methoxy-benzenesulfonyl)-2-methyl-1H-indol-3-yl]-methyl}-(2-phenylsulfanyl-ethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

C10H16O4 (80664-28-4) + [1-[1-(4-Methoxy-benzenesulfonyl)-2-methyl-1H-indol-3-yl]-meth-(E)-ylidene]-(2-phenylsulfanyl-ethyl)-amine (82946-36-9) → cis-4a-ethyl-1,3,4,4a,5,6,7,11c-octahydro-7-<(p-methoxyphenyl)sulfonyl>-1-<2-(phenylthio)ethyl>-2H-pyrido<3,2-c>carbazol-2-one (80664-29-5) + 4-Methylene-hexanoic acid {ethoxy-[1-(4-methoxy-benzenesulfonyl)-2-methyl-1H-indol-3-yl]-methyl}-(2-phenylsulfanyl-ethyl)-amide (80664-30-8)

Guidance literature:

In chlorobenzene; at 140 ℃; for 2.75h;

DOI:10.1021/ja00368a058

Reference yield: 21.0%

C10H16O4 (80664-28-4) + (E)-1-<(p-methoxyphenyl)sulfonyl>-2-methyl-3-indole (80664-27-3) → cis-4a-ethyl-1,3,4,4a,5,6,7,11c-octahydro-7-<(p-methoxyphenyl)sulfonyl>-1-<2-(phenylthio)ethyl>-2H-pyrido<3,2-c>carbazol-2-one (80664-29-5) + 4-Methylene-hexanoic acid {ethoxy-[1-(4-methoxy-benzenesulfonyl)-2-methyl-1H-indol-3-yl]-methyl}-(2-phenylsulfanyl-ethyl)-amide (80664-30-8)

Guidance literature:

In chlorobenzene; at 135 ℃; for 2.75h;

DOI:10.1021/ja00352a037

Reference yield:

2-methyl-1H-indole-3-carbaldehyde (5416-80-8) → 4-Methylene-hexanoic acid {ethoxy-[1-(4-methoxy-benzenesulfonyl)-2-methyl-1H-indol-3-yl]-methyl}-(2-phenylsulfanyl-ethyl)-amide (80664-30-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) sodium hydride, 2.) imidazole / 1.) glyme, 20 deg C, 1.5 h, reflux, 15 min, 2.) 20 deg C, 15 h

2: CH₂Cl₂ / 15 h / 4 Angstroem molecular sieves

3: 21 percent / chlorobenzene / 2.75 h / 135 °C

With 1H-imidazole; sodium hydride; In dichloromethane; chlorobenzene;

DOI:10.1021/ja00352a037

upstream raw materials:

C₁₀H₁₆O₄

[1-[1-(4-Methoxy-benzenesulfonyl)-2-methyl-1H-indol-3-yl]-meth-(E)-ylidene]-(2-phenylsulfanyl-ethyl)-amine

(E)-1-<(p-methoxyphenyl)sulfonyl>-2-methyl-3-indole

2-methyl-1H-indole-3-carbaldehyde