5-[4''-(5'''-aminobenzo[d]oxazol-2'''-yl)-2''-fluorophenyl]-2'-deoxyuridine

Base Information

Chemical Name:5-[4''-(5'''-aminobenzo[d]oxazol-2'''-yl)-2''-fluorophenyl]-2'-deoxyuridine
CAS No.:1352918-31-0
Molecular Formula:C₂₂H₁₉FN₄O₆
Molecular Weight:454.414
Hs Code.:

Synonyms:5-[4''-(5'''-aminobenzo[d]oxazol-2'''-yl)-2''-fluorophenyl]-2'-deoxyuridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-[4''-(5'''-aminobenzo[d]oxazol-2'''-yl)-2''-fluorophenyl]-2'-deoxyuridine

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Technology Process of 5-[4''-(5'''-aminobenzo[d]oxazol-2'''-yl)-2''-fluorophenyl]-2'-deoxyuridine

There total 4 articles about 5-[4''-(5'''-aminobenzo[d]oxazol-2'''-yl)-2''-fluorophenyl]-2'-deoxyuridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1352918-23-0
5-amino-2-(4'-pinacolatoboronyl-3'-fluorophenyl)-1,3-benzoxazole

: 54-42-2,162239-35-2
5-Iodo-2'-deoxyuridine

: 1352918-31-0
5-[4''-(5'''-aminobenzo[d]oxazol-2'''-yl)-2''-fluorophenyl]-2'-deoxyuridine

Guidance literature:: With palladium diacetate; caesium carbonate; In water; acetonitrile; at 80 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jo202321g

Reference yield:

: 137-09-7,1794-30-5,29849-01-2
2,4-diaminophenol hydrochloride

: 1352918-31-0
5-[4''-(5'''-aminobenzo[d]oxazol-2'''-yl)-2''-fluorophenyl]-2'-deoxyuridine

Guidance literature:: Multi-step reaction with 3 steps

1: polyphosphoric acid / N,N-dimethyl-formamide / 16 h / 170 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 4 h / 80 °C / Inert atmosphere

3: palladium diacetate; caesium carbonate / water; acetonitrile / 2 h / 80 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; palladium diacetate; caesium carbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile; 1: Suzuki coupling / 3: Suzuki coupling;
DOI:10.1021/jo202321g

Reference yield:

: 1159548-85-2
5-amino-2-(4'-bromo-3'-fluorophenyl)-1,3-benzoxazole

: 1352918-31-0
5-[4''-(5'''-aminobenzo[d]oxazol-2'''-yl)-2''-fluorophenyl]-2'-deoxyuridine

Guidance literature:: Multi-step reaction with 2 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 4 h / 80 °C / Inert atmosphere

2: palladium diacetate; caesium carbonate / water; acetonitrile / 2 h / 80 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; palladium diacetate; caesium carbonate; In 1,4-dioxane; water; acetonitrile; 2: Suzuki coupling;
DOI:10.1021/jo202321g