(S)-3-Amino-2-{[3-bromo-5-(3-hydroxy-benzylcarbamoyl)-thiophene-2-carbonyl]-amino}-propionic acid methyl ester trifluoro-acetic acid salt

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Chemical Name:(S)-3-Amino-2-{[3-bromo-5-(3-hydroxy-benzylcarbamoyl)-thiophene-2-carbonyl]-amino}-propionic acid methyl ester trifluoro-acetic acid salt
CAS No.:1400662-72-7
Molecular Formula:C₂HF₃O₂*C₁₇H₁₈BrN₃O₅S
Molecular Weight:570.341
Hs Code.:

Synonyms:(S)-3-Amino-2-{[3-bromo-5-(3-hydroxy-benzylcarbamoyl)-thiophene-2-carbonyl]-amino}-propionic acid methyl ester trifluoro-acetic acid salt

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Chemical Property of (S)-3-Amino-2-{[3-bromo-5-(3-hydroxy-benzylcarbamoyl)-thiophene-2-carbonyl]-amino}-propionic acid methyl ester trifluoro-acetic acid salt

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Technology Process of (S)-3-Amino-2-{[3-bromo-5-(3-hydroxy-benzylcarbamoyl)-thiophene-2-carbonyl]-amino}-propionic acid methyl ester trifluoro-acetic acid salt

There total 4 articles about (S)-3-Amino-2-{[3-bromo-5-(3-hydroxy-benzylcarbamoyl)-thiophene-2-carbonyl]-amino}-propionic acid methyl ester trifluoro-acetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1400662-69-2
(S)-2-{[3-Bromo-5-(3-hydroxy-benzylcarbamoyl)-thiophene-2-carbonyl]-amino}-3-tert-butoxycarbonylamino-propionic acid methyl ester

: 76-05-1
trifluoroacetic acid

: 1400662-72-7
(S)-3-Amino-2-{[3-bromo-5-(3-hydroxy-benzylcarbamoyl)-thiophene-2-carbonyl]-amino}-propionic acid methyl ester trifluoro-acetic acid salt

Guidance literature:: In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 76575-71-8
5-methyl-3-aminothiophene-2-carboxylic acid methyl ester

: 1400662-72-7
(S)-3-Amino-2-{[3-bromo-5-(3-hydroxy-benzylcarbamoyl)-thiophene-2-carbonyl]-amino}-propionic acid methyl ester trifluoro-acetic acid salt

Guidance literature:: Multi-step reaction with 8 steps

1.1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 1.5 h / 0 - 20 °C

2.1: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 15 h / Reflux; pressure tube

3.1: sodium hydrogencarbonate / dimethyl sulfoxide / 3 h / 115 °C

4.1: periodic acid / acetonitrile / 0.5 h

4.2: 2 h

5.1: triethylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 15 h / 20 °C

6.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 15 h

7.1: triethylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 15 h / 20 °C

8.1: dichloromethane / 1 h / 20 °C

With N-Bromosuccinimide; tert.-butylnitrite; lithium hydroxide monohydrate; water; sodium hydrogencarbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; periodic acid; triethylamine; copper(ll) bromide; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1257535-60-6
methyl 3-bromo-5-methylthiophene-2-carboxylate

: 1400662-72-7
(S)-3-Amino-2-{[3-bromo-5-(3-hydroxy-benzylcarbamoyl)-thiophene-2-carbonyl]-amino}-propionic acid methyl ester trifluoro-acetic acid salt

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 15 h / Reflux; pressure tube

2.1: sodium hydrogencarbonate / dimethyl sulfoxide / 3 h / 115 °C

3.1: periodic acid / acetonitrile / 0.5 h

3.2: 2 h

4.1: triethylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 15 h / 20 °C

5.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 15 h

6.1: triethylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 15 h / 20 °C

7.1: dichloromethane / 1 h / 20 °C

With N-Bromosuccinimide; lithium hydroxide monohydrate; water; sodium hydrogencarbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; periodic acid; triethylamine; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;