4-(9-chloro-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepin-4-yl)benzeneethanol

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Chemical Name:4-(9-chloro-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepin-4-yl)benzeneethanol
CAS No.:1378963-37-1
Molecular Formula:C₂₀H₁₉ClN₂O
Molecular Weight:338.837
Hs Code.:

Synonyms:4-(9-chloro-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepin-4-yl)benzeneethanol

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Chemical Property of 4-(9-chloro-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepin-4-yl)benzeneethanol

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Technology Process of 4-(9-chloro-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepin-4-yl)benzeneethanol

There total 5 articles about 4-(9-chloro-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepin-4-yl)benzeneethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 2.5%

: 1378963-96-2
C₁₁H₁₁ClN₂*ClH

: 163164-46-3
4-[2-(tetrahydropyran-2-yloxy)-ethyl]benzaldehyde

: 1378963-37-1
4-(9-chloro-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepin-4-yl)benzeneethanol

Guidance literature:: C₁₁H₁₁ClN₂*ClH; In dichloromethane; Basic conditions;

4-[2-(tetrahydropyran-2-yloxy)-ethyl]benzaldehyde; With acetic acid; In dichloromethane; for 120h;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 38487-86-4
2-amino-4-chlorobenzonitrile

: 1378963-37-1
4-(9-chloro-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepin-4-yl)benzeneethanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / 0.5 h / Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.03 h / Cooling with ice

2.2: 0.5 h / Cooling with ice

3.1: dichloromethane / Basic conditions

3.2: 120 h

With lithium aluminium tetrahydride; acetic acid; In tetrahydrofuran; dichloromethane;

Reference yield:

: 4654-39-1
4-bromophenethanol

: 1378963-37-1
4-(9-chloro-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepin-4-yl)benzeneethanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridinium p-toluenesulfonate / dichloromethane / 10 h / 25 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Anhydrous conditions

2.2: 2 h / -78 °C

3.1: dichloromethane / Basic conditions

3.2: 120 h

With n-butyllithium; pyridinium p-toluenesulfonate; In tetrahydrofuran; hexane; dichloromethane;