(6-bromopyridin-2-yl)-(3-methoxy-4-methylphenyl)-methanol

Base Information

• Chemical Name: (6-bromopyridin-2-yl)-(3-methoxy-4-methylphenyl)-methanol
• CAS No.: 1357564-31-8
• Molecular Formula: C₁₄H₁₄BrNO₂
• Molecular Weight: 308.175
• Mol file: 1357564-31-8.mol

Synonyms:(6-bromopyridin-2-yl)-(3-methoxy-4-methylphenyl)-methanol

Chemical Property of (6-bromopyridin-2-yl)-(3-methoxy-4-methylphenyl)-methanol

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (6-bromopyridin-2-yl)-(3-methoxy-4-methylphenyl)-methanol

There total 1 articles about (6-bromopyridin-2-yl)-(3-methoxy-4-methylphenyl)-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

6-bromo-2-pyridinecarbaldehyde (34160-40-2) + 5-bromo-2-methylphenol methyl ether (67868-73-9) → (6-bromopyridin-2-yl)-(3-methoxy-4-methylphenyl)-methanol (1357564-31-8)

Guidance literature:

5-bromo-2-methylphenol methyl ether; With magnesium; In tetrahydrofuran; at 60 ℃; for 2h; Inert atmosphere;

6-bromo-2-pyridinecarbaldehyde; In tetrahydrofuran; at 80 ℃; Inert atmosphere;

With water; sodium chloride; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.ejmech.2011.09.004

Reference yield: 98.0%

(6-bromopyridin-2-yl)-(3-methoxy-4-methylphenyl)-methanol (1357564-31-8) → (6-bromopyridin-2-yl)-(3-methoxy-4-methylphenyl)-methanone (1357564-33-0)

Guidance literature:

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; at 60 ℃;

DOI:10.1016/j.ejmech.2011.09.004

Reference yield:

(6-bromopyridin-2-yl)-(3-methoxy-4-methylphenyl)-methanol (1357564-31-8) → (3-hydroxy-4-methylphenyl)-[6-(4-hydroxy-3-methylphenyl)-pyridin-2-yl]-methanone (1357563-54-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / tetrahydrofuran / 60 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,2-dimethoxyethane; water / 80 °C / Inert atmosphere

3: boron dimethyl-trifluoro sulphide / dichloromethane / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron dimethyl-trifluoro sulphide; caesium carbonate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; 2: Suzuki coupling;

DOI:10.1016/j.ejmech.2011.09.004

upstream raw materials:

6-bromo-2-pyridinecarbaldehyde

5-bromo-2-methylphenol methyl ether

Downstream raw materials:

(6-bromopyridin-2-yl)-(3-methoxy-4-methylphenyl)-methanone

(3-methoxy-4-methylphenyl)-[6-(4-methoxy-3-methylphenyl)-pyridin-2-yl]-methanone

(3-hydroxy-4-methylphenyl)-[6-(4-hydroxy-3-methylphenyl)-pyridin-2-yl]-methanone