1H-Pyrrolo[3,2-c]pyridine-1-carboxylicacid, 3-iodo-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: 1H-Pyrrolo[3,2-c]pyridine-1-carboxylicacid, 3-iodo-, 1,1-dimethylethyl ester
• CAS No.: 877060-48-5
• Molecular Formula: C12H13 I N2 O2
• Molecular Weight: 344.15
• Hs Code.: 2933990090
• Mol file: 877060-48-5.mol

Synonyms:3-Iodopyrrolo[3,2-c]pyridine-1-carboxylicacid tert-butyl ester

Chemical Property of 1H-Pyrrolo[3,2-c]pyridine-1-carboxylicacid, 3-iodo-, 1,1-dimethylethyl ester

Chemical Property:

• PSA: 44.12000
• LogP: 3.42410
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99%, ^*data from raw suppliers

tert-Butyl 3-iodopyrrolo[3,2-c]pyridine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrolo[3,2-c]pyridine-1-carboxylicacid, 3-iodo-, 1,1-dimethylethyl ester

There total 3 articles about 1H-Pyrrolo[3,2-c]pyridine-1-carboxylicacid, 3-iodo-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-iodo-1H-pyrrolo[3,2-c]pyridine (877060-47-4) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 3-iodo-1H-pyrrolo[3,2-c]pyridine-1-carboxylate (877060-48-5)

Guidance literature:

With dmap; In tetrahydrofuran; at 20 ℃; for 16h;

DOI:10.1055/s-2005-916028

Reference yield:

5-azaindole (271-34-1) → tert-butyl 3-iodo-1H-pyrrolo[3,2-c]pyridine-1-carboxylate (877060-48-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / KOH; I₂ / dimethylformamide / 0.25 h / 20 °C

2: 100 percent / DMAP / tetrahydrofuran / 16 h / 20 °C

With dmap; potassium hydroxide; iodine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1055/s-2005-916028

Reference yield:

→ tert-butyl 3-iodo-1H-pyrrolo[3,2-c]pyridine-1-carboxylate (877060-48-5)

Guidance literature:

upstream raw materials:

3-iodo-1H-pyrrolo[3,2-c]pyridine

di-tert-butyl dicarbonate

5-azaindole

Downstream raw materials:

1-tert-butyloxycarbonyl-3-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pyrrolo[3,2-c]pyridine

3-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-pyrrolo[3,2-c]pyridine

C₂₁H₂₁N₅O₂

phenyl[4-(1H-pyrrolo[3,2-c]pyridin-3-yl)pyrimidin-2-yl]-amine

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