N-benzyl-(S)-α,α-di(1-naphthyl)-2-pyrrolidinemethanol

Base Information

Chemical Name:N-benzyl-(S)-α,α-di(1-naphthyl)-2-pyrrolidinemethanol
CAS No.:944810-50-8
Molecular Formula:C₃₂H₂₉NO
Molecular Weight:443.588
Hs Code.:

Synonyms:N-benzyl-(S)-α,α-di(1-naphthyl)-2-pyrrolidinemethanol

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Chemical Property of N-benzyl-(S)-α,α-di(1-naphthyl)-2-pyrrolidinemethanol

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Technology Process of N-benzyl-(S)-α,α-di(1-naphthyl)-2-pyrrolidinemethanol

There total 3 articles about N-benzyl-(S)-α,α-di(1-naphthyl)-2-pyrrolidinemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 90-11-9
1-Bromonaphthalene

: 83528-04-5
(S)-N-benzyl-O-benzylpyrrolidine-2-carboxylate

: 944810-50-8
N-benzyl-(S)-α,α-di(1-naphthyl)-2-pyrrolidinemethanol

Guidance literature:: 1-Bromonaphthalene; With n-butyllithium; In tetrahydrofuran; at -78 ℃; Inert atmosphere;

(S)-N-benzyl-O-benzylpyrrolidine-2-carboxylate; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

With ammonium hydroxide; ammonium chloride; In tetrahydrofuran; water; at 20 ℃; Inert atmosphere;
DOI:10.1021/ol200043n

Reference yield: 54.0%

: 113304-84-0,127986-89-4
N-benzyl-(S)-proline methyl ester

: 703-55-9
1-naphthylmagnesiumbromide

: 944810-50-8
N-benzyl-(S)-α,α-di(1-naphthyl)-2-pyrrolidinemethanol

Guidance literature:: N-benzyl-(S)-proline methyl ester; 1-naphthylmagnesiumbromide; In tetrahydrofuran; at 0 ℃; Reflux;

With ammonium chloride; In tetrahydrofuran; at 0 ℃;
DOI:10.1080/00304948.2011.613697

Reference yield: 49.0%

: 580-13-2
2-bromonaphthalene

: 113304-84-0,127986-89-4
N-benzyl-(S)-proline methyl ester

: 944810-50-8
N-benzyl-(S)-α,α-di(1-naphthyl)-2-pyrrolidinemethanol

Guidance literature:: 2-bromonaphthalene; With iodine; magnesium; In tetrahydrofuran; at 50 ℃; for 1h; Inert atmosphere;

N-benzyl-(S)-proline methyl ester; In tetrahydrofuran; at 20 ℃; for 20h; Inert atmosphere;
DOI:10.1002/anie.202012760