2-[2-(4-chloro-phenyl)-5-methyl-pyrimidin-4-yl]-4-[1-(tetrahydro-pyran-4-yl)meth-(E)-ylidene]cyclopentane-1,3-dione

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Chemical Name:2-[2-(4-chloro-phenyl)-5-methyl-pyrimidin-4-yl]-4-[1-(tetrahydro-pyran-4-yl)meth-(E)-ylidene]cyclopentane-1,3-dione
CAS No.:1262512-42-4
Molecular Formula:C₂₂H₂₁ClN₂O₃
Molecular Weight:396.873
Hs Code.:

Synonyms:2-[2-(4-chloro-phenyl)-5-methyl-pyrimidin-4-yl]-4-[1-(tetrahydro-pyran-4-yl)meth-(E)-ylidene]cyclopentane-1,3-dione

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Chemical Property of 2-[2-(4-chloro-phenyl)-5-methyl-pyrimidin-4-yl]-4-[1-(tetrahydro-pyran-4-yl)meth-(E)-ylidene]cyclopentane-1,3-dione

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Technology Process of 2-[2-(4-chloro-phenyl)-5-methyl-pyrimidin-4-yl]-4-[1-(tetrahydro-pyran-4-yl)meth-(E)-ylidene]cyclopentane-1,3-dione

There total 6 articles about 2-[2-(4-chloro-phenyl)-5-methyl-pyrimidin-4-yl]-4-[1-(tetrahydro-pyran-4-yl)meth-(E)-ylidene]cyclopentane-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1262512-40-2
2-[2-(4-chloro-phenyl)-5-methyl-pyrimidin-4-yl]-5-[hydroxy-(tetrahydro-pyran-4-yl)methyl]-3-methoxy-cyclopent-2-enone

: 1262512-42-4
2-[2-(4-chloro-phenyl)-5-methyl-pyrimidin-4-yl]-4-[1-(tetrahydro-pyran-4-yl)meth-(E)-ylidene]cyclopentane-1,3-dione

Guidance literature:: With hydrogenchloride; water; In 1,4-dioxane; at 60 ℃; for 13h;

Reference yield:

: 115297-57-9
4-chlorobenzene-1-carboximidamide hydrogeniodide

: 1262512-42-4
2-[2-(4-chloro-phenyl)-5-methyl-pyrimidin-4-yl]-4-[1-(tetrahydro-pyran-4-yl)meth-(E)-ylidene]cyclopentane-1,3-dione

Guidance literature:: Multi-step reaction with 6 steps

1.1: ethanol; sodium / 1 h / 20 °C / Inert atmosphere

1.2: 20 °C

1.3: pH 1

2.1: trichlorophosphate / 2 h / Reflux

3.1: potassium phosphate / palladium diacetate; XPhos / 1,4-dioxane / 0.5 h / 150 °C / microwave irradiation

4.1: potassium carbonate / acetone / 0.08 h / 20 °C

4.2: 3 h / Reflux

5.1: lithium diisopropyl amide / tetrahydrofuran; hexane; ethylbenzene / 0.75 h / -78 °C / Inert atmosphere

5.2: -78 - 20 °C

6.1: hydrogenchloride; water / 1,4-dioxane / 13 h / 60 °C

With hydrogenchloride; potassium phosphate; ethanol; water; sodium; potassium carbonate; lithium diisopropyl amide; trichlorophosphate; palladium diacetate; XPhos; In tetrahydrofuran; 1,4-dioxane; hexane; ethylbenzene; acetone;

Reference yield:

: 180606-47-7
2-(4-chloro-phenyl)-5-methyl-3H-pyrimidin-4-one

: 1262512-42-4
2-[2-(4-chloro-phenyl)-5-methyl-pyrimidin-4-yl]-4-[1-(tetrahydro-pyran-4-yl)meth-(E)-ylidene]cyclopentane-1,3-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: trichlorophosphate / 2 h / Reflux

2.1: potassium phosphate / palladium diacetate; XPhos / 1,4-dioxane / 0.5 h / 150 °C / microwave irradiation

3.1: potassium carbonate / acetone / 0.08 h / 20 °C

3.2: 3 h / Reflux

4.1: lithium diisopropyl amide / tetrahydrofuran; hexane; ethylbenzene / 0.75 h / -78 °C / Inert atmosphere

4.2: -78 - 20 °C

5.1: hydrogenchloride; water / 1,4-dioxane / 13 h / 60 °C

With hydrogenchloride; potassium phosphate; water; potassium carbonate; lithium diisopropyl amide; trichlorophosphate; palladium diacetate; XPhos; In tetrahydrofuran; 1,4-dioxane; hexane; ethylbenzene; acetone;