(3S)-N-[(3-{[3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-3-morpholinecarboxamide

Base Information

Chemical Name:(3S)-N-[(3-{[3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-3-morpholinecarboxamide
CAS No.:1361330-07-5
Molecular Formula:C₂₈H₃₀FN₅O₅S
Molecular Weight:567.641
Hs Code.:

Synonyms:(3S)-N-[(3-{[3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-3-morpholinecarboxamide

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Chemical Property of (3S)-N-[(3-{[3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-3-morpholinecarboxamide

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Technology Process of (3S)-N-[(3-{[3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-3-morpholinecarboxamide

There total 5 articles about (3S)-N-[(3-{[3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-3-morpholinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1361330-54-2
C₃₃H₃₈FN₅O₇S

: 1361330-07-5
(3S)-N-[(3-{[3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-3-morpholinecarboxamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 21 ℃; for 1h;

Reference yield:

: 1240518-02-8
3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}-benzonitrile

: 1361330-07-5
(3S)-N-[(3-{[3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-3-morpholinecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / 21 h / 21 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 2 h / 0 °C

3.1: HATU / N,N-dimethyl-formamide / 0.05 h

3.2: 0.05 h

3.3: 3 h

4.1: trifluoroacetic acid / dichloromethane / 1 h / 21 °C

With pyridine; lithium aluminium tetrahydride; HATU; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 886362-07-8
4-(methyloxy)-1H-indazol-3-amine

: 1361330-07-5
(3S)-N-[(3-{[3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-3-morpholinecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 0.33 h / 20 °C / Inert atmosphere

2.1: pyridine / 21 h / 21 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 2 h / 0 °C

4.1: HATU / N,N-dimethyl-formamide / 0.05 h

4.2: 0.05 h

4.3: 3 h

5.1: trifluoroacetic acid / dichloromethane / 1 h / 21 °C

With pyridine; lithium aluminium tetrahydride; HATU; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;