2-(difluoromethanesulfonyl)-1,3-benzothiazole

Base Information

• Chemical Name: 2-(difluoromethanesulfonyl)-1,3-benzothiazole
• CAS No.: 186204-66-0
• Molecular Formula: C₈H₅F₂NO₂S₂
• Molecular Weight: 249.262
• Mol file: 186204-66-0.mol

Synonyms:2-(difluoromethanesulfonyl)-1,3-benzothiazole

Chemical Property of 2-(difluoromethanesulfonyl)-1,3-benzothiazole

Chemical Property:

• Melting Point: 133-135 °C
• Boiling Point: 348.4±52.0 °C(Predicted)
• Density: 1.564±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

2-((Difluoromethyl)sulfonyl)benzo[d]thiazole 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(difluoromethanesulfonyl)-1,3-benzothiazole

There total 9 articles about 2-(difluoromethanesulfonyl)-1,3-benzothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-(benzo[d]thiazol-2-ylsulfonyl)-1-(4-bromophenyl)-2,2-difluoroethanone (1241899-81-9) → 2-(difluoromethanesulfonyl)-1,3-benzothiazole (186204-66-0)

Guidance literature:

With water; sodium hydroxide; at 20 ℃; for 0.5h;

DOI:10.1016/j.jfluchem.2009.12.022

Reference yield: 90.0%

2-[(difluoromethyl)sulfanyl]-1,3-benzothiazole (943-08-8) → 2-(difluoromethanesulfonyl)-1,3-benzothiazole (186204-66-0)

Guidance literature:

With sodium periodate; ruthenium(III) trichloride hydrate; water; In tetrachloromethane; acetonitrile; at 20 ℃; for 5h;

DOI:10.1021/ol100090r

Reference yield: 63.0%

ethyl 2-(benzo[d]thiazol-2-ylsulfonyl)-2,2-difluoroacetate (477889-77-3) → 2-(difluoromethanesulfonyl)-1,3-benzothiazole (186204-66-0)

Guidance literature:

With water; 1,8-diazabicyclo[5.4.0]undec-7-ene; In ethyl acetate; at 20 ℃; for 16h;

DOI:10.1016/j.tet.2009.03.041

upstream raw materials:

ethyl α-(1,3-benzothiazol-2-ylsulfonyl)-α-fluoroacetate

ethyl 2-(benzo[d]thiazol-2-ylsulfonyl)-2,2-difluoroacetate

2-(benzo[d]thiazol-2-ylsulfonyl)-1-(4-bromophenyl)-2,2-difluoroethanone

2-[(difluoromethyl)sulfanyl]-1,3-benzothiazole

Downstream raw materials:

C₁₇H₁₅F₂NO₂S₂

2,6-anhydro-1-deoxy-1,1-difluoro-3,4,5,7-tetrakis-O-benzyl-D-gluco-hept-1-enitol

sodium difluoromethanesulfinate

2-methanesulfonylbenzothiazole