(S)-diethyl ((4-benzyl-4,5-dihydrooxazol-2-yl)methyl)phosphonate

Base Information

• Chemical Name: (S)-diethyl ((4-benzyl-4,5-dihydrooxazol-2-yl)methyl)phosphonate
• CAS No.: 1557101-75-3
• Molecular Formula: C₁₅H₂₂NO₄P
• Molecular Weight: 311.318
• Mol file: 1557101-75-3.mol

Synonyms:(S)-diethyl ((4-benzyl-4,5-dihydrooxazol-2-yl)methyl)phosphonate

Chemical Property of (S)-diethyl ((4-benzyl-4,5-dihydrooxazol-2-yl)methyl)phosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-diethyl ((4-benzyl-4,5-dihydrooxazol-2-yl)methyl)phosphonate

There total 4 articles about (S)-diethyl ((4-benzyl-4,5-dihydrooxazol-2-yl)methyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(S)-2-(2-diethoxyphosphoryl)acetamide-3-phenylbromopropane (1557101-78-6) → (S)-diethyl ((4-benzyl-4,5-dihydrooxazol-2-yl)methyl)phosphonate (1557101-75-3)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.tetasy.2013.12.003

Reference yield: 32.0%

(S)-2-[2-(diethoxyphosphoryl)acetamide] 2-benzylethanol (1378030-79-5) → (S)-diethyl ((4-benzyl-4,5-dihydrooxazol-2-yl)methyl)phosphonate (1557101-75-3)

Guidance literature:

With potassium carbonate; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In dichloromethane; at -20 ℃;

DOI:10.1016/j.tetasy.2013.12.003

Reference yield:

diethylphosphonoacetic acid (3095-95-2) → (S)-diethyl ((4-benzyl-4,5-dihydrooxazol-2-yl)methyl)phosphonate (1557101-75-3)

Guidance literature:

Multi-step reaction with 2 steps

1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 12 h / 20 °C / Inert atmosphere

2: (bis-(2-methoxyethyl)amino)sulfur trufluoride; potassium carbonate / dichloromethane / -20 °C

With dmap; potassium carbonate; dicyclohexyl-carbodiimide; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In dichloromethane;

DOI:10.1016/j.tetasy.2013.12.003

upstream raw materials:

(S)-2-[2-(diethoxyphosphoryl)acetamide] 2-benzylethanol

(S)-2-(2-diethoxyphosphoryl)acetamide-3-phenylbromopropane

diethylphosphonoacetic acid

L-Phenylalaninol