5-phenyl-3-[(2'R,3'S)-3'-hydroxy-2'-dimethoxymethyltetrahydrofuran-3'-yl]-1,2,4-oxadiazole

Base Information

Chemical Name:5-phenyl-3-[(2'R,3'S)-3'-hydroxy-2'-dimethoxymethyltetrahydrofuran-3'-yl]-1,2,4-oxadiazole
CAS No.:287183-66-8
Molecular Formula:C₁₅H₁₈N₂O₅
Molecular Weight:306.318
Hs Code.:

Synonyms:5-phenyl-3-[(2'R,3'S)-3'-hydroxy-2'-dimethoxymethyltetrahydrofuran-3'-yl]-1,2,4-oxadiazole

Suppliers and Price of 5-phenyl-3-[(2'R,3'S)-3'-hydroxy-2'-dimethoxymethyltetrahydrofuran-3'-yl]-1,2,4-oxadiazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-phenyl-3-[(2'R,3'S)-3'-hydroxy-2'-dimethoxymethyltetrahydrofuran-3'-yl]-1,2,4-oxadiazole

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 5-phenyl-3-[(2'R,3'S)-3'-hydroxy-2'-dimethoxymethyltetrahydrofuran-3'-yl]-1,2,4-oxadiazole

There total 5 articles about 5-phenyl-3-[(2'R,3'S)-3'-hydroxy-2'-dimethoxymethyltetrahydrofuran-3'-yl]-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 287183-61-3
(2R,3S)-3-benzoyloxy-3-cyano-2-dimethoxymethyltetrahydrofuran

: 2-(R)-dimethoxymethyl-3-oximido-tetrahydrofuran

: 287183-66-8
5-phenyl-3-[(2'R,3'S)-3'-hydroxy-2'-dimethoxymethyltetrahydrofuran-3'-yl]-1,2,4-oxadiazole

Guidance literature:: With hydroxylamine; In methanol; for 2h; Heating;
DOI:10.1016/S0957-4166(00)00095-1

Reference yield:

: 89860-19-5
(1R,2R,5R)-2-(dimethoxymethyl)-3,6-dioxabicyclo[3.1.0]hexane

: 287183-66-8
5-phenyl-3-[(2'R,3'S)-3'-hydroxy-2'-dimethoxymethyltetrahydrofuran-3'-yl]-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 5 steps

1: 58 percent / LiAlH₄ / tetrahydrofuran / Heating

2: 92.6 percent / pyridinium dichromate; Ac₂O / CH₂Cl₂ / 1 h / Heating

3: HOAc / CH₂Cl₂ / 2 h / 0 °C

4: 24.7 percent / pyridine / 20 °C

5: 42 percent / hydroxylamine / methanol / 2 h / Heating

With pyridine; lithium aluminium tetrahydride; dipyridinium dichromate; hydroxylamine; acetic anhydride; acetic acid; In tetrahydrofuran; methanol; dichloromethane; 1: Reduction / 2: Oxidation / 3: Addition / 4: Acylation / 5: cyclocondensation;
DOI:10.1016/S0957-4166(00)00095-1

Reference yield:

: 287183-59-9
2-(S)-dimethoxymethyl-3-keto-tetrahydrofuran

: 287183-66-8
5-phenyl-3-[(2'R,3'S)-3'-hydroxy-2'-dimethoxymethyltetrahydrofuran-3'-yl]-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1: HOAc / CH₂Cl₂ / 2 h / 0 °C

2: 24.7 percent / pyridine / 20 °C

3: 42 percent / hydroxylamine / methanol / 2 h / Heating

With pyridine; hydroxylamine; acetic acid; In methanol; dichloromethane; 1: Addition / 2: Acylation / 3: cyclocondensation;
DOI:10.1016/S0957-4166(00)00095-1