Bis<<<-D-seryl>-N-methyl-L-alanyl>-S-(acetamidomethyl)-L-cysteinyl>-L-valie> Dilactone

Base Information

• Chemical Name: Bis<<<-D-seryl>-N-methyl-L-alanyl>-S-(acetamidomethyl)-L-cysteinyl>-L-valie> Dilactone
• CAS No.: 78186-13-7
• Molecular Formula: C₅₂H₇₄N₁₀O₁₆S₂
• Molecular Weight: 1159.35

Synonyms:Bis<<<-D-seryl>-N-methyl-L-alanyl>-S-(acetamidomethyl)-L-cysteinyl>-L-valie> Dilactone

Chemical Property of Bis<<<-D-seryl>-N-methyl-L-alanyl>-S-(acetamidomethyl)-L-cysteinyl>-L-valie> Dilactone

Chemical Property:

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Technology Process of Bis<<<-D-seryl>-N-methyl-L-alanyl>-S-(acetamidomethyl)-L-cysteinyl>-L-valie> Dilactone

There total 1 articles about Bis<<<-D-seryl>-N-methyl-L-alanyl>-S-(acetamidomethyl)-L-cysteinyl>-L-valie> Dilactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

-O-<<<-O-<-S-(acetamidomethyl)-L-cysteinyl>-L-valyl>-D-seryl>-N-methyl-L-alanyl>-S-(acetamidomethyl)-L-cysteinyl>-L-valyl>-D-seryl>-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester (78166-96-8) → Bis<<<-D-seryl>-N-methyl-L-alanyl>-S-(acetamidomethyl)-L-cysteinyl>-L-valie> Dilactone (78186-13-7)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; zinc; Yield given. Multistep reaction;

DOI:10.1021/jo00330a010

Reference yield: 87.5%

Bis<<<-D-seryl>-N-methyl-L-alanyl>-S-(acetamidomethyl)-L-cysteinyl>-L-valie> Dilactone (78186-13-7) → Bis<<<-D-seryl>-N-methyl-L-alanyl>-L-cysteinyl>-L-valine>Serine Hydroxyl Dilactone Disulfide (78186-14-8)

Guidance literature:

With iodine; In methanol; for 6h;

DOI:10.1021/jo00330a010

Reference yield:

Bis<<<-D-seryl>-N-methyl-L-alanyl>-S-(acetamidomethyl)-L-cysteinyl>-L-valie> Dilactone (78186-13-7) → 2,MeAla6>-Des-N-tetramethyltriostin A (78186-11-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 87.5 percent / iodine / methanol / 6 h

2: 1.) 32percent hydrogen bromide in glacial acetic acid, 2.) triethylamine / 1.) 45 min., room temperature, 2.) DMF, 0 deg C, 30 min., 3.) room temperature, 22 h, 4.) 50 deg C, 2 h

With hydrogen bromide; iodine; triethylamine; In methanol;

DOI:10.1021/jo00330a010

upstream raw materials:

-O-<<<-O-<-S-(acetamidomethyl)-L-cysteinyl>-L-valyl>-D-seryl>-N-methyl-L-alanyl>-S-(acetamidomethyl)-L-cysteinyl>-L-valyl>-D-seryl>-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester

Downstream raw materials:

Bis<<<-D-seryl>-N-methyl-L-alanyl>-L-cysteinyl>-L-valine>Serine Hydroxyl Dilactone Disulfide

2,MeAla⁶>-Des-N-tetramethyltriostin A

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