5-fluoro-2-(6-fluoro-2-methyl-1H-benzimidazol-1-yl)-N-(4-methoxyphenyl)pyrimidine-4,6-diamine

Base Information

Chemical Name:5-fluoro-2-(6-fluoro-2-methyl-1H-benzimidazol-1-yl)-N-(4-methoxyphenyl)pyrimidine-4,6-diamine
CAS No.:1610965-40-6
Molecular Formula:C₁₉H₁₆F₂N₆O
Molecular Weight:382.372
Hs Code.:

Synonyms:5-fluoro-2-(6-fluoro-2-methyl-1H-benzimidazol-1-yl)-N-(4-methoxyphenyl)pyrimidine-4,6-diamine

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Chemical Property of 5-fluoro-2-(6-fluoro-2-methyl-1H-benzimidazol-1-yl)-N-(4-methoxyphenyl)pyrimidine-4,6-diamine

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Technology Process of 5-fluoro-2-(6-fluoro-2-methyl-1H-benzimidazol-1-yl)-N-(4-methoxyphenyl)pyrimidine-4,6-diamine

There total 4 articles about 5-fluoro-2-(6-fluoro-2-methyl-1H-benzimidazol-1-yl)-N-(4-methoxyphenyl)pyrimidine-4,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1610966-64-7
6-chloro-5-fluoro-2-(6-fluoro-2-methyl-1H-benzo[d]imidazol-1-yl)-N-(4-methoxyphenyl)pyrimidin-4-amine

: 1610965-40-6
5-fluoro-2-(6-fluoro-2-methyl-1H-benzimidazol-1-yl)-N-(4-methoxyphenyl)pyrimidine-4,6-diamine

Guidance literature:: With ammonium hydroxide; In dimethyl sulfoxide; at 100 ℃; for 18h;

Reference yield:

: 367-31-7
4-fluoro-1,2-phenylenediamine

: 1610965-40-6
5-fluoro-2-(6-fluoro-2-methyl-1H-benzimidazol-1-yl)-N-(4-methoxyphenyl)pyrimidine-4,6-diamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1 h / 180 °C / Microwave irradiation

2.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / -78 - 20 °C

2.2: 0.25 h / -78 °C

3.1: ethanol / 1 h / 60 °C

4.1: ammonium hydroxide / dimethyl sulfoxide / 18 h / 100 °C

With ammonium hydroxide; sodium hydride; In tetrahydrofuran; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 118469-15-1
6-fluoro-2-methyl-1H-benzo[d]imidazole

: 1610965-40-6
5-fluoro-2-(6-fluoro-2-methyl-1H-benzimidazol-1-yl)-N-(4-methoxyphenyl)pyrimidine-4,6-diamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / -78 - 20 °C

1.2: 0.25 h / -78 °C

2.1: ethanol / 1 h / 60 °C

3.1: ammonium hydroxide / dimethyl sulfoxide / 18 h / 100 °C

With ammonium hydroxide; sodium hydride; In tetrahydrofuran; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;