C₂₇H₂₄F₄N₂O₃

Base Information

Chemical Name:C₂₇H₂₄F₄N₂O₃
CAS No.:1610370-07-4
Molecular Formula:C₂₇H₂₄F₄N₂O₃
Molecular Weight:500.493
Hs Code.:

C<sub>27</sub>H<sub>24</sub>F<sub>4</sub>N<sub>2</sub>O<sub>3</sub>

Synonyms:C₂₇H₂₄F₄N₂O₃

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₂₇H₂₄F₄N₂O₃

Chemical Property:

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Technology Process of C₂₇H₂₄F₄N₂O₃

There total 16 articles about C₂₇H₂₄F₄N₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: C₂₇H₂₄F₄N₂O₃

: 1610370-07-4
C₂₇H₂₄F₄N₂O₃

: 1610370-06-3
C₂₇H₂₄F₄N₂O₃

Guidance literature:: With Chiralpak AD-H SFC, 250 x 21 mm ID, 5 μιη;; In methanol; Resolution of racemate;

Reference yield:

: 1610370-14-3
2′-fluoro-5′-methoxy-3-methylbiphenyl-4-carboxylic acid

: 1610370-07-4
C₂₇H₂₄F₄N₂O₃

: 1610370-06-3
C₂₇H₂₄F₄N₂O₃

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

2.1: triethylamine; methanesulfonyl chloride; lithium bromide / tetrahydrofuran / 1.5 h / 0 °C

3.1: zinc; ethylene dibromide; chloro-trimethyl-silane / tetrahydrofuran / 2 h / 65 °C / Inert atmosphere

3.2: 20 - 80 °C / Inert atmosphere

4.1: water; lithium hydroxide / tetrahydrofuran / 20 °C

5.1: Chiralpak AD-H SFC, 250 x 21 mm ID, 5 μιη; / methanol / Resolution of racemate

With lithium aluminium tetrahydride; chloro-trimethyl-silane; water; methanesulfonyl chloride; ethylene dibromide; triethylamine; lithium bromide; lithium hydroxide; zinc; In tetrahydrofuran; methanol;

Reference yield:

: 589-21-9
(4-bromophenyl)hydrazine

: 1610370-07-4
C₂₇H₂₄F₄N₂O₃

: 1610370-06-3
C₂₇H₂₄F₄N₂O₃

Guidance literature:: Multi-step reaction with 10 steps

1.1: tetrahydrofuran / 0 - 20 °C

2.1: benzenesulfonyl chloride; N-ethyl-N,N-diisopropylamine / ethyl acetate / 3 h / 0 - 20 °C

3.1: triethylamine / toluene / 40 °C

4.1: lithium borohydride / tetrahydrofuran / 3.5 h / 0 - 20 °C

5.1: triethylamine / dichloromethane / 0 - 20 °C

6.1: triethylamine / dimethyl sulfoxide / 4 h / 60 °C

7.1: hydrogenchloride / dichloromethane; acetic acid methyl ester / 20 °C

8.1: zinc; ethylene dibromide; chloro-trimethyl-silane / tetrahydrofuran / 2 h / 65 °C / Inert atmosphere

8.2: 20 - 80 °C / Inert atmosphere

9.1: water; lithium hydroxide / tetrahydrofuran / 20 °C

10.1: Chiralpak AD-H SFC, 250 x 21 mm ID, 5 μιη; / methanol / Resolution of racemate

With hydrogenchloride; lithium borohydride; chloro-trimethyl-silane; water; ethylene dibromide; triethylamine; N-ethyl-N,N-diisopropylamine; benzenesulfonyl chloride; lithium hydroxide; zinc; In tetrahydrofuran; methanol; dichloromethane; acetic acid methyl ester; dimethyl sulfoxide; ethyl acetate; toluene;