3-CHLOROMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: 3-CHLOROMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• CAS No.: 876589-13-8
• Molecular Formula: C10H18 Cl N O2
• Molecular Weight: 219.71
• Hs Code.: 2933990090
• Mol file: 876589-13-8.mol

Synonyms:tert-Butyl3-(chloromethyl)-1-pyrrolidinecarboxylate

Chemical Property of 3-CHLOROMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Chemical Property:

• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.477
• Boiling Point: 284.3°C at 760 mmHg
• Flash Point: 125.7°C
• PSA: 29.54000
• Density: 1.101g/cm³
• LogP: 2.42010

Purity/Quality:

97% ^*data from raw suppliers

3-Chloromethyl-pyrrolidine-1-carboxylicAcidtert-butylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-CHLOROMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

There total 2 articles about 3-CHLOROMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

→ tert‐butyl-3‐(chloromethyl)pyrrolidine‐1‐carboxylate (876589-13-8)

Guidance literature:

Reference yield:

tert-butyl 3-(hydroxymethyl)pyrrolidine-1-carboxylate (114214-69-6) → tert‐butyl-3‐(chloromethyl)pyrrolidine‐1‐carboxylate (876589-13-8)

Guidance literature:

With PS-PPh₃; In tetrachloromethane; dichloromethane;

DOI:10.1016/j.bmcl.2010.02.053

Reference yield: 91.0%

tert‐butyl-3‐(chloromethyl)pyrrolidine‐1‐carboxylate (876589-13-8) + 3,4-dichlorothiophenol (5858-17-3) → tert‐butyl 3‐{[(3,4‐dichlorophenyl)sulfanyl]methyl}pyrrolidine‐1‐carboxylate

Guidance literature:

3,4-dichlorothiophenol; With potassium carbonate; In ethanol; for 0.166667h; Reflux;

tert‐butyl-3‐(chloromethyl)pyrrolidine‐1‐carboxylate; In ethanol; at 80 ℃;

DOI:10.1021/acs.jmedchem.1c00497

upstream raw materials:

tert-butyl 3-(hydroxymethyl)pyrrolidine-1-carboxylate

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