1,3,2',6',2''',6'''-hexa-N-(tert-butoxycarbonyl)-5''-deoxy-5''-(4-(β-alanyl(Fmoc)-Trp(Boc)-NHBn)-[1,2,3]-triazol-1-yl)-neomycin

Base Information

• Chemical Name: 1,3,2',6',2''',6'''-hexa-N-(tert-butoxycarbonyl)-5''-deoxy-5''-(4-(β-alanyl(Fmoc)-Trp(Boc)-NHBn)-[1,2,3]-triazol-1-yl)-neomycin
• CAS No.: 1134204-72-0
• Molecular Formula: C₉₆H₁₃₅N₁₃O₃₀
• Molecular Weight: 1951.2
• Mol file: 1134204-72-0.mol

Synonyms:1,3,2',6',2''',6'''-hexa-N-(tert-butoxycarbonyl)-5''-deoxy-5''-(4-(β-alanyl(Fmoc)-Trp(Boc)-NHBn)-[1,2,3]-triazol-1-yl)-neomycin

Chemical Property of 1,3,2',6',2''',6'''-hexa-N-(tert-butoxycarbonyl)-5''-deoxy-5''-(4-(β-alanyl(Fmoc)-Trp(Boc)-NHBn)-[1,2,3]-triazol-1-yl)-neomycin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3,2',6',2''',6'''-hexa-N-(tert-butoxycarbonyl)-5''-deoxy-5''-(4-(β-alanyl(Fmoc)-Trp(Boc)-NHBn)-[1,2,3]-triazol-1-yl)-neomycin

There total 1 articles about 1,3,2',6',2''',6'''-hexa-N-(tert-butoxycarbonyl)-5''-deoxy-5''-(4-(β-alanyl(Fmoc)-Trp(Boc)-NHBn)-[1,2,3]-triazol-1-yl)-neomycin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

5″-azide-1,3,2′,6′,2′″,6′″-hexa-N-(tert-butoxycarbonyl)-5″-deoxy-neomycin B (849676-07-9) + Fmoc-Pra-Trp-NHBn (1134204-66-2) → 1,3,2',6',2''',6'''-hexa-N-(tert-butoxycarbonyl)-5''-deoxy-5''-(4-(β-alanyl(Fmoc)-Trp(Boc)-NHBn)-[1,2,3]-triazol-1-yl)-neomycin (1134204-72-0)

Guidance literature:

With copper(l) iodide; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃;

DOI:10.1016/j.bmcl.2010.03.116

Reference yield: 90.0%

1,3,2',6',2''',6'''-hexa-N-(tert-butoxycarbonyl)-5''-deoxy-5''-(4-(β-alanyl(Fmoc)-Trp(Boc)-NHBn)-[1,2,3]-triazol-1-yl)-neomycin (1134204-72-0) + trifluoroacetic acid (76-05-1) → 1,3,2',6',2''',6'''-hexaammonium-5''-(4-(β-alanyl(Fmoc)-Trp-NHBn)-[1,2,3]-triazol-1-yl)-5''-deoxyneomycin-hexakis(trifluoroacetate)

Guidance literature:

at 0 ℃; for 0.05h;

DOI:10.1016/j.bmcl.2010.03.116

upstream raw materials:

5″-azide-1,3,2′,6′,2′″,6′″-hexa-N-(tert-butoxycarbonyl)-5″-deoxy-neomycin B

Fmoc-Pra-Trp-NHBn