(S)-2-(4-(cyclopropylsulfonyl)-1H-pyrazolo[3,4-c]pyridin-1-yl)-3-(tetrahydro-2H-pyran-4-yl)propanoate (R)-N-(4-(dimethylamino)benzyl)-1-phenylethanaminium salt

Base Information

Chemical Name:(S)-2-(4-(cyclopropylsulfonyl)-1H-pyrazolo[3,4-c]pyridin-1-yl)-3-(tetrahydro-2H-pyran-4-yl)propanoate (R)-N-(4-(dimethylamino)benzyl)-1-phenylethanaminium salt
CAS No.:1373168-71-8
Molecular Formula:C₁₇H₂₁N₃O₅S*C₁₇H₂₂N₂
Molecular Weight:633.812
Hs Code.:

(S)-2-(4-(cyclopropylsulfonyl)-1H-pyrazolo[3,4-c]pyridin-1-yl)-3-(tetrahydro-2H-pyran-4-yl)propanoate (R)-N-(4-(dimethylamino)benzyl)-1-phenylethanaminium salt

Synonyms:(S)-2-(4-(cyclopropylsulfonyl)-1H-pyrazolo[3,4-c]pyridin-1-yl)-3-(tetrahydro-2H-pyran-4-yl)propanoate (R)-N-(4-(dimethylamino)benzyl)-1-phenylethanaminium salt

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Chemical Property of (S)-2-(4-(cyclopropylsulfonyl)-1H-pyrazolo[3,4-c]pyridin-1-yl)-3-(tetrahydro-2H-pyran-4-yl)propanoate (R)-N-(4-(dimethylamino)benzyl)-1-phenylethanaminium salt

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Technology Process of (S)-2-(4-(cyclopropylsulfonyl)-1H-pyrazolo[3,4-c]pyridin-1-yl)-3-(tetrahydro-2H-pyran-4-yl)propanoate (R)-N-(4-(dimethylamino)benzyl)-1-phenylethanaminium salt

There total 17 articles about (S)-2-(4-(cyclopropylsulfonyl)-1H-pyrazolo[3,4-c]pyridin-1-yl)-3-(tetrahydro-2H-pyran-4-yl)propanoate (R)-N-(4-(dimethylamino)benzyl)-1-phenylethanaminium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1217776-45-8
(R)-N,N-dimethyl-4-((1-phenylethylamino)methyl)aniline

: 1373168-69-4
2-(4-(cyclopropylsulfonyl)-1H-pyrazolo[3,4-c]pyridin-1-yl)-3-(tetrahydro-2H-pyran-4-yl)propanoic acid

: 1373168-71-8
(S)-2-(4-(cyclopropylsulfonyl)-1H-pyrazolo[3,4-c]pyridin-1-yl)-3-(tetrahydro-2H-pyran-4-yl)propanoate (R)-N-(4-(dimethylamino)benzyl)-1-phenylethanaminium salt

Guidance literature:: In water; isopropyl alcohol; at 20 - 70 ℃; Industry scale;

Reference yield:

: 40500-10-5
3-(tetrahydro-2H-pyran-4-yl)propanoic acid

: 1373168-71-8
(S)-2-(4-(cyclopropylsulfonyl)-1H-pyrazolo[3,4-c]pyridin-1-yl)-3-(tetrahydro-2H-pyran-4-yl)propanoate (R)-N-(4-(dimethylamino)benzyl)-1-phenylethanaminium salt

Guidance literature:: Multi-step reaction with 7 steps

1.1: thionyl chloride / N,N-dimethyl-formamide / chlorobenzene / 1.5 h / 21 °C

2.1: bromine / chlorobenzene / 20 h / 85 - 90 °C

3.1: water / chlorobenzene / 21 h / 0 - 5 °C

4.1: sulfurous dibromide / 16 h / 40 - 60 °C / Industry scale

5.1: caesium carbonate / butanone / 0.28 h / Industry scale

5.2: 13.8 h / 54 °C / Industry scale

6.1: sodium hydroxide; water / butanone / 1.72 h / 12 - 18 °C / Industry scale

6.2: 3 h / pH 3.2 / Industry scale

7.1: isopropyl alcohol; water / 20 - 70 °C / Industry scale

With sulfurous dibromide; thionyl chloride; water; bromine; caesium carbonate; sodium hydroxide; N,N-dimethyl-formamide; In water; chlorobenzene; isopropyl alcohol; butanone;

Reference yield:

: 5337-03-1
tetrahydro-2H-pyran-4-carboxylic acid

: 1373168-71-8
(S)-2-(4-(cyclopropylsulfonyl)-1H-pyrazolo[3,4-c]pyridin-1-yl)-3-(tetrahydro-2H-pyran-4-yl)propanoate (R)-N-(4-(dimethylamino)benzyl)-1-phenylethanaminium salt

Guidance literature:: Multi-step reaction with 13 steps

1.1: magnesium chloride / tetrahydrofuran / 2.5 h / 10 - 50 °C / Industry scale

1.2: 18.5 h / 30 - 34 °C / Industry scale

2.1: sodium tetrahydroborate / 1.42 h / 10 - 39 °C

2.2: 0 - 5 °C

3.1: dmap / tetrahydrofuran / 3 h / 20 - 35 °C

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 24 h / 35 - 50 °C

5.1: hydrogen / palladium(II) hydroxide / ethanol / 5 h / 30 °C / 155.15 Torr

6.1: sodium hydroxide; water / ethanol / 16 h

6.2: 1 h / 0 - 5 °C / pH 1

7.1: thionyl chloride / N,N-dimethyl-formamide / chlorobenzene / 1.5 h / 21 °C

8.1: bromine / chlorobenzene / 20 h / 85 - 90 °C

9.1: water / chlorobenzene / 21 h / 0 - 5 °C

10.1: sulfurous dibromide / 16 h / 40 - 60 °C / Industry scale

11.1: caesium carbonate / butanone / 0.28 h / Industry scale

11.2: 13.8 h / 54 °C / Industry scale

12.1: sodium hydroxide; water / butanone / 1.72 h / 12 - 18 °C / Industry scale

12.2: 3 h / pH 3.2 / Industry scale

13.1: isopropyl alcohol; water / 20 - 70 °C / Industry scale

With dmap; sodium tetrahydroborate; sulfurous dibromide; thionyl chloride; water; hydrogen; bromine; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide; magnesium chloride; palladium(II) hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol; water; chlorobenzene; isopropyl alcohol; butanone;