(E)-(S)-5-((2R,6R)-6-Ethyl-5-methyl-3,6-dihydro-2H-pyran-2-yl)-3-methyl-2-(toluene-4-sulfonyl)-hex-4-enoic acid methyl ester

Base Information

Chemical Name:(E)-(S)-5-((2R,6R)-6-Ethyl-5-methyl-3,6-dihydro-2H-pyran-2-yl)-3-methyl-2-(toluene-4-sulfonyl)-hex-4-enoic acid methyl ester
CAS No.:130799-15-4
Molecular Formula:C₂₃H₃₂O₅S
Molecular Weight:420.57
Hs Code.:

Synonyms:(E)-(S)-5-((2R,6R)-6-Ethyl-5-methyl-3,6-dihydro-2H-pyran-2-yl)-3-methyl-2-(toluene-4-sulfonyl)-hex-4-enoic acid methyl ester

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Chemical Property of (E)-(S)-5-((2R,6R)-6-Ethyl-5-methyl-3,6-dihydro-2H-pyran-2-yl)-3-methyl-2-(toluene-4-sulfonyl)-hex-4-enoic acid methyl ester

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Technology Process of (E)-(S)-5-((2R,6R)-6-Ethyl-5-methyl-3,6-dihydro-2H-pyran-2-yl)-3-methyl-2-(toluene-4-sulfonyl)-hex-4-enoic acid methyl ester

There total 9 articles about (E)-(S)-5-((2R,6R)-6-Ethyl-5-methyl-3,6-dihydro-2H-pyran-2-yl)-3-methyl-2-(toluene-4-sulfonyl)-hex-4-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 455-16-3
p-toluenesulfonyl fluoride

: (E)-(R)-5-((2R,6R)-6-Ethyl-5-methyl-3,6-dihydro-2H-pyran-2-yl)-3-methyl-hex-4-enoic acid methyl ester

: 130799-15-4
(E)-(S)-5-((2R,6R)-6-Ethyl-5-methyl-3,6-dihydro-2H-pyran-2-yl)-3-methyl-2-(toluene-4-sulfonyl)-hex-4-enoic acid methyl ester

Guidance literature:: With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; 1.) -78 deg C, 1 h; 2.) RT, 24 h;
DOI:10.1016/S0040-4020(01)88025-X

Reference yield:

: 105247-06-1
(E)-3-methyl-1,3-hexadiene

: 130799-15-4
(E)-(S)-5-((2R,6R)-6-Ethyl-5-methyl-3,6-dihydro-2H-pyran-2-yl)-3-methyl-2-(toluene-4-sulfonyl)-hex-4-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: hydroquinone / CHCl₃ / 12 h / 120 °C

3: 1.) (COCl)2, DMF, 2.) PhCH₂PdCl(PPh₃)2 / 1.) CH₂Cl₂, 0 deg C - 20 deg C, 2 h, 2.) HMPA, 70 deg C, 3 h

4: 92 percent / tetrahydrofuran / 2 h / 0 °C

6: 92 percent / diethyl ether / Ambient temperature

7: 1.) LDA / 1.) THF, -78 deg C, 2.) -78 deg C to RT, 24 h

With oxalyl dichloride; trans benzyl(chloro)bis(triphenylphosphine)palladium(II); N,N-dimethyl-formamide; hydroquinone; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; chloroform;

Reference yield:

: 130799-11-0
(E)-1-((2R,6R)-6-Ethyl-5-methyl-3,6-dihydro-2H-pyran-2-yl)-but-2-en-1-one

: 130799-15-4
(E)-(S)-5-((2R,6R)-6-Ethyl-5-methyl-3,6-dihydro-2H-pyran-2-yl)-3-methyl-2-(toluene-4-sulfonyl)-hex-4-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / tetrahydrofuran / 2 h / 0 °C

3: 92 percent / diethyl ether / Ambient temperature

4: 1.) LDA / 1.) THF, -78 deg C, 2.) -78 deg C to RT, 24 h

With lithium diisopropyl amide; In tetrahydrofuran; diethyl ether;