ethyl (S)-3-((S)-2-(4,4-bis(trifluoromethyl)-3-(4-(3-(2-methylphenyl)ureido)-3-methoxybenzyl)-2,5-dioxoimidazolidin-1-yl)-2-(cyclopropylmethyl)acetylamino)-3-phenylpropionate

Base Information

Chemical Name:ethyl (S)-3-((S)-2-(4,4-bis(trifluoromethyl)-3-(4-(3-(2-methylphenyl)ureido)-3-methoxybenzyl)-2,5-dioxoimidazolidin-1-yl)-2-(cyclopropylmethyl)acetylamino)-3-phenylpropionate
CAS No.:457059-32-4
Molecular Formula:C₃₈H₃₉F₆N₅O₇
Molecular Weight:791.747
Hs Code.:

ethyl (S)-3-((S)-2-(4,4-bis(trifluoromethyl)-3-(4-(3-(2-methylphenyl)ureido)-3-methoxybenzyl)-2,5-dioxoimidazolidin-1-yl)-2-(cyclopropylmethyl)acetylamino)-3-phenylpropionate

Synonyms:ethyl (S)-3-((S)-2-(4,4-bis(trifluoromethyl)-3-(4-(3-(2-methylphenyl)ureido)-3-methoxybenzyl)-2,5-dioxoimidazolidin-1-yl)-2-(cyclopropylmethyl)acetylamino)-3-phenylpropionate

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Chemical Property of ethyl (S)-3-((S)-2-(4,4-bis(trifluoromethyl)-3-(4-(3-(2-methylphenyl)ureido)-3-methoxybenzyl)-2,5-dioxoimidazolidin-1-yl)-2-(cyclopropylmethyl)acetylamino)-3-phenylpropionate

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Technology Process of ethyl (S)-3-((S)-2-(4,4-bis(trifluoromethyl)-3-(4-(3-(2-methylphenyl)ureido)-3-methoxybenzyl)-2,5-dioxoimidazolidin-1-yl)-2-(cyclopropylmethyl)acetylamino)-3-phenylpropionate

There total 10 articles about ethyl (S)-3-((S)-2-(4,4-bis(trifluoromethyl)-3-(4-(3-(2-methylphenyl)ureido)-3-methoxybenzyl)-2,5-dioxoimidazolidin-1-yl)-2-(cyclopropylmethyl)acetylamino)-3-phenylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 3082-69-7
ethyl (3S)-3-amino-3-phenylpropionate

: 457059-31-3
(S)-2-[4,4-bis(trifluoromethyl)-3-(4-(3-(2-methylphenyl)ureido)-3-methoxybenzyl)-2,5-dioxoimidazolidin-1-yl]-2-(cyclopropylmethyl)acetic acid

: 457059-32-4
ethyl (S)-3-((S)-2-(4,4-bis(trifluoromethyl)-3-(4-(3-(2-methylphenyl)ureido)-3-methoxybenzyl)-2,5-dioxoimidazolidin-1-yl)-2-(cyclopropylmethyl)acetylamino)-3-phenylpropionate

Guidance literature:: With O-[(ethoxycarbonyl)cyanomethyleneamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate; diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1016/j.tet.2004.03.025

Reference yield:

: 80866-88-2
(3-methoxy-4-nitrophenyl)methanol

: 457059-32-4
ethyl (S)-3-((S)-2-(4,4-bis(trifluoromethyl)-3-(4-(3-(2-methylphenyl)ureido)-3-methoxybenzyl)-2,5-dioxoimidazolidin-1-yl)-2-(cyclopropylmethyl)acetylamino)-3-phenylpropionate

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / Pd/C / various solvent(s) / cooling

2: 20.5 g / various solvent(s) / 0.5 h

3: 75 percent / thionyl chloride / CH₂Cl₂ / 3 h / 20 °C

4: 57 percent / n-BuLi / hexane; tetrahydrofuran / 3 h / 20 °C

5: 82 percent / TOTU; N,N-diisopropylamine / dimethylformamide / 1 h / 20 °C

With n-butyllithium; thionyl chloride; O-[(ethoxycarbonyl)cyanomethyleneamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate; hydrogen; diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2004.03.025

Reference yield:

: 102735-53-5,15785-52-1
(2S)-2-amino-3-cyclopropylpropanoic acid

: 457059-32-4
ethyl (S)-3-((S)-2-(4,4-bis(trifluoromethyl)-3-(4-(3-(2-methylphenyl)ureido)-3-methoxybenzyl)-2,5-dioxoimidazolidin-1-yl)-2-(cyclopropylmethyl)acetylamino)-3-phenylpropionate

Guidance literature:: Multi-step reaction with 7 steps

1: 84 percent / H₂SO₄ / dioxane / 24 h / 20 °C

2: 76 percent / CH₂Cl₂ / 20 °C

3: diphosgene; triethylamine / CH₂Cl₂ / -30 - -15 °C

4: 3.70 g / benzene / Heating

5: trifluoroacetic acid / CH₂Cl₂

6: 57 percent / n-BuLi / hexane; tetrahydrofuran / 3 h / 20 °C

7: 82 percent / TOTU; N,N-diisopropylamine / dimethylformamide / 1 h / 20 °C

With n-butyllithium; O-[(ethoxycarbonyl)cyanomethyleneamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate; sulfuric acid; triethylamine; diisopropylamine; trifluoroacetic acid; trichloromethyl chloroformate; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1016/j.tet.2004.03.025