Benzoic acid (1R,2R,4R,5S)-4-(tert-butyl-dimethyl-silanyloxy)-2-methoxymethoxy-2-methyl-5-(2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclopentyl ester

Base Information

Chemical Name:Benzoic acid (1R,2R,4R,5S)-4-(tert-butyl-dimethyl-silanyloxy)-2-methoxymethoxy-2-methyl-5-(2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclopentyl ester
CAS No.:863975-78-4
Molecular Formula:C₂₇H₄₃NO₆Si
Molecular Weight:505.727
Hs Code.:

Synonyms:Benzoic acid (1R,2R,4R,5S)-4-(tert-butyl-dimethyl-silanyloxy)-2-methoxymethoxy-2-methyl-5-(2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclopentyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzoic acid (1R,2R,4R,5S)-4-(tert-butyl-dimethyl-silanyloxy)-2-methoxymethoxy-2-methyl-5-(2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclopentyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of Benzoic acid (1R,2R,4R,5S)-4-(tert-butyl-dimethyl-silanyloxy)-2-methoxymethoxy-2-methyl-5-(2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclopentyl ester

There total 3 articles about Benzoic acid (1R,2R,4R,5S)-4-(tert-butyl-dimethyl-silanyloxy)-2-methoxymethoxy-2-methyl-5-(2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclopentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 639467-31-5
(1R,4S)-1-[(tert-butyldimethylsilyl)oxy]-4-methylcyclopent-2-en-4-ol

: 863975-78-4
Benzoic acid (1R,2R,4R,5S)-4-(tert-butyl-dimethyl-silanyloxy)-2-methoxymethoxy-2-methyl-5-(2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclopentyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 85 percent / toluene / 48 h / Heating

2.1: 80 percent / 18-crown-6; NaHCO₃; potassium peroxymonosulfate / CH₂Cl₂; acetone; H₂O / 2 h / 0 °C

3.1: 81 percent / diisopropylethylamine / CH₂Cl₂ / 48 h / 20 °C

4.1: toluene / Heating

4.2: 81 percent / pyridine / CH₂Cl₂

With Oxone; 18-crown-6 ether; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; acetone; toluene;
DOI:10.1002/hlca.200590124

Reference yield:

: 832078-85-0
(3aS,4R,6R,6aR)-4-{[tert-butyl(dimethyl)silyl]oxy}-3,3a,4,5,6,6a-hexahydro-6-hydroxy-6-methyl-2H-cyclopenta[b]furan-2-one

: 863975-78-4
Benzoic acid (1R,2R,4R,5S)-4-(tert-butyl-dimethyl-silanyloxy)-2-methoxymethoxy-2-methyl-5-(2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclopentyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 81 percent / diisopropylethylamine / CH₂Cl₂ / 48 h / 20 °C

2.1: toluene / Heating

2.2: 81 percent / pyridine / CH₂Cl₂

With N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene;
DOI:10.1002/hlca.200590124

Reference yield:

: 832078-84-9
2-[(1S,5R)-5-{[tert-butyl(dimethyl)silyl]oxy}3-mehylcyclopent-2-en-1-yl]-N,N-dimethylacetamide

: 863975-78-4
Benzoic acid (1R,2R,4R,5S)-4-(tert-butyl-dimethyl-silanyloxy)-2-methoxymethoxy-2-methyl-5-(2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclopentyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 80 percent / 18-crown-6; NaHCO₃; potassium peroxymonosulfate / CH₂Cl₂; acetone; H₂O / 2 h / 0 °C

2.1: 81 percent / diisopropylethylamine / CH₂Cl₂ / 48 h / 20 °C

3.1: toluene / Heating

3.2: 81 percent / pyridine / CH₂Cl₂

With Oxone; 18-crown-6 ether; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; acetone; toluene;
DOI:10.1002/hlca.200590124