α-(dimethylamino)methyl-1-<(2-fluorophenyl)phenylmethyl>-1H-pyrrole-2-methanol

Base Information

Chemical Name:α-(dimethylamino)methyl-1-<(2-fluorophenyl)phenylmethyl>-1H-pyrrole-2-methanol
CAS No.:120098-63-7
Molecular Formula:C₂₁H₂₃FN₂O
Molecular Weight:338.425
Hs Code.:

Synonyms:α-(dimethylamino)methyl-1-<(2-fluorophenyl)phenylmethyl>-1H-pyrrole-2-methanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of α-(dimethylamino)methyl-1-<(2-fluorophenyl)phenylmethyl>-1H-pyrrole-2-methanol

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Technology Process of α-(dimethylamino)methyl-1-<(2-fluorophenyl)phenylmethyl>-1H-pyrrole-2-methanol

There total 4 articles about α-(dimethylamino)methyl-1-<(2-fluorophenyl)phenylmethyl>-1H-pyrrole-2-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 153837-04-8
1-<<(2-fluorophenyl)phenylmethyl>pyrrol-2-yl>-2-dimethylaminoethanone

: 120098-63-7
α-(dimethylamino)methyl-1-<(2-fluorophenyl)phenylmethyl>-1H-pyrrole-2-methanol

Guidance literature:: With sodium tetrahydroborate; In isopropyl alcohol; for 6h; Heating;
DOI:10.1002/jhet.5570300132

Reference yield:

: 55095-24-4
α-(2-fluorophenyl)benzenemethanamine

: 120098-63-7
α-(dimethylamino)methyl-1-<(2-fluorophenyl)phenylmethyl>-1H-pyrrole-2-methanol

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / acetic acid / 1.5 h / Heating

2: 1.) zinc chloride, hydrogen chloride, 2.) H₂O / 1.) Et₂O, 6 h, 2.) 95 deg C, 2 h

3: 89 percent / methanol / 2 h / 85 °C

4: 83 percent / NaBH₄ / propan-2-ol / 6 h / Heating

With hydrogenchloride; sodium tetrahydroborate; water; zinc(II) chloride; In methanol; acetic acid; isopropyl alcohol;
DOI:10.1002/jhet.5570300132

Reference yield:

: 120098-72-8
1-<(2-fluorophenyl)phenylmethyl>pyrrole

: 120098-63-7
α-(dimethylamino)methyl-1-<(2-fluorophenyl)phenylmethyl>-1H-pyrrole-2-methanol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) zinc chloride, hydrogen chloride, 2.) H₂O / 1.) Et₂O, 6 h, 2.) 95 deg C, 2 h

2: 89 percent / methanol / 2 h / 85 °C

3: 83 percent / NaBH₄ / propan-2-ol / 6 h / Heating

With hydrogenchloride; sodium tetrahydroborate; water; zinc(II) chloride; In methanol; isopropyl alcohol;
DOI:10.1002/jhet.5570300132