2-Bromo-1-(6-methylpyridin-2-yl)ethanone

Base Information

• Chemical Name: 2-Bromo-1-(6-methylpyridin-2-yl)ethanone
• CAS No.: 88625-09-6
• Molecular Formula: C8H8 Br N O
• Molecular Weight: 214.05922
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID10600555
• Wikidata: Q82496696
• Mol file: 88625-09-6.mol

Synonyms:88625-09-6;2-bromo-1-(6-methylpyridin-2-yl)ethanone;2-Bromo-1-(6-methylpyridin-2-yl)ethan-1-one;Ethanone, 2-bromo-1-(6-methyl-2-pyridinyl)- (9CI);2-bromo-1-(6-methyl-2-pyridinyl)ethanone;2-bromoacetyl-6-methylpyridine;SCHEMBL4307414;DTXSID10600555;UTOCGDHGZVWDAJ-UHFFFAOYSA-N;AMY42500;MFCD13173279;AKOS017560207;2-Bromo-1-(6-methyl-2-pyridyl)ethanone;SY284216;Ethanone,2-bromo-1-(6-methyl-2-pyridinyl)-;F53403;EN300-2944769;A903255

Chemical Property of 2-Bromo-1-(6-methylpyridin-2-yl)ethanone

Chemical Property:

• PSA: 29.96000
• LogP: 1.96760
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 212.97893
• Heavy Atom Count: 11
• Complexity: 149

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC(=CC=C1)C(=O)CBr

Technology Process of 2-Bromo-1-(6-methylpyridin-2-yl)ethanone

There total 3 articles about 2-Bromo-1-(6-methylpyridin-2-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-acetyl-6-methylpyridine (6940-57-4) → 2-bromo-1-(6-methylpyridin-2-yl)ethan-1-one (88625-09-6)

Guidance literature:

With hydrogen bromide; bromine; acetic acid; at 0 - 20 ℃; for 1h;

Reference yield:

2-Cyano-6-methylpyridine (1620-75-3) → 2-bromo-1-(6-methylpyridin-2-yl)ethan-1-one (88625-09-6)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 5 h / -20 °C

2: hydrogen bromide; bromine; acetic acid / 1 h / 0 - 20 °C

With hydrogen bromide; bromine; acetic acid; In tetrahydrofuran;

Reference yield:

→ 2-bromo-1-(6-methylpyridin-2-yl)ethan-1-one (88625-09-6)

Guidance literature:

2-Methyl-6-acetyl-pyridin, Br2, in CCl4, Siedetemp., 1/2 h;

DOI:10.1021/jm50016a014

upstream raw materials:

2-Cyano-6-methylpyridine

2-acetyl-6-methylpyridine