ethyl (R)-2-hydroxy-4-phenyl-2-(trifluoromethyl)but-3-ynoate

Base Information

Chemical Name:ethyl (R)-2-hydroxy-4-phenyl-2-(trifluoromethyl)but-3-ynoate
CAS No.:1258456-56-2
Molecular Formula:C₁₃H₁₁F₃O₃
Molecular Weight:272.224
Hs Code.:

Synonyms:ethyl (R)-2-hydroxy-4-phenyl-2-(trifluoromethyl)but-3-ynoate

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Chemical Property of ethyl (R)-2-hydroxy-4-phenyl-2-(trifluoromethyl)but-3-ynoate

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Technology Process of ethyl (R)-2-hydroxy-4-phenyl-2-(trifluoromethyl)but-3-ynoate

There total 2 articles about ethyl (R)-2-hydroxy-4-phenyl-2-(trifluoromethyl)but-3-ynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 13081-18-0
ethyl-3,3,3-trifluoropyruvate

: 2170-06-1
1-Phenyl-2-(trimethylsilyl)acetylene

: 1258456-56-2
ethyl (R)-2-hydroxy-4-phenyl-2-(trifluoromethyl)but-3-ynoate

Guidance literature:: ethyl-3,3,3-trifluoropyruvate; 1-Phenyl-2-(trimethylsilyl)acetylene; With silver hexafluoroantimonate; [(R)-(+)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl]palladium(II) chloride; In dichloromethane; at 0 - 20 ℃; for 24h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 4h; optical yield given as %ee; enantioselective reaction;
DOI:10.1021/ol102541s

Reference yield:

: 13081-18-0
ethyl-3,3,3-trifluoropyruvate

: 536-74-3
phenylacetylene

: 1258456-56-2
ethyl (R)-2-hydroxy-4-phenyl-2-(trifluoromethyl)but-3-ynoate

: 1315273-00-7
ethyl (S)-2-hydroxy-4-phenyl-2-(trifluoromethyl)but-3-ynoate

Guidance literature:: With C₂₅H₃₀N₂O₇Rh; In diethyl ether; at 25 ℃; for 24h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1002/anie.201100252

Reference yield: 71.0%

: 1258456-56-2
ethyl (R)-2-hydroxy-4-phenyl-2-(trifluoromethyl)but-3-ynoate

: 1258456-76-6
C₁₁H₇F₃O₃

Guidance literature:: ethyl (R)-2-hydroxy-4-phenyl-2-(trifluoromethyl)but-3-ynoate; With water; sodium hydroxide; In methanol; at 20 - 60 ℃; for 12h;

With hydrogenchloride; In methanol; water; pH=3;
DOI:10.1021/ol102541s