N,N-Diethyl-4-[5-(4-methoxyphenyl)-1H-pyrrol-3-yl]benzenemethanamine

Base Information

Chemical Name:N,N-Diethyl-4-[5-(4-methoxyphenyl)-1H-pyrrol-3-yl]benzenemethanamine
CAS No.:862201-40-9
Molecular Formula:C₂₂H₂₆N₂O
Molecular Weight:334.461
Hs Code.:
DSSTox Substance ID:DTXSID401160459

Synonyms:DTXSID401160459;N,N-Diethyl-4-[5-(4-methoxyphenyl)-1H-pyrrol-3-yl]benzenemethanamine;862201-40-9

Suppliers and Price of N,N-Diethyl-4-[5-(4-methoxyphenyl)-1H-pyrrol-3-yl]benzenemethanamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N,N-Diethyl-4-[5-(4-methoxyphenyl)-1H-pyrrol-3-yl]benzenemethanamine

Chemical Property:

XLogP3:4.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:7
Exact Mass:334.204513457
Heavy Atom Count:25
Complexity:368

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCN(CC)CC1=CC=C(C=C1)C2=CNC(=C2)C3=CC=C(C=C3)OC

Technology Process of N,N-Diethyl-4-[5-(4-methoxyphenyl)-1H-pyrrol-3-yl]benzenemethanamine

There total 5 articles about N,N-Diethyl-4-[5-(4-methoxyphenyl)-1H-pyrrol-3-yl]benzenemethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-(4-diethylaminomethyl-phenyl)-4,4-dimethoxy-1-(4-methoxy-phenyl)-butan-1-one

: 862201-40-9
diethyl-{4-[5-(4-methoxyphenyl)-1H-pyrrol-3-yl]benzyl}-amine

Guidance literature:: With ammonium acetate; acetic acid; at 100 ℃; for 1h;
DOI:10.1021/jo050696k

Reference yield:

: 82413-58-9
4-[(diethylamino)methyl]-benzaldehyde

: 862201-40-9
diethyl-{4-[5-(4-methoxyphenyl)-1H-pyrrol-3-yl]benzyl}-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 93 percent / NaOH / ethanol / 16 h / Heating

2.1: 86 percent / Et₂NH / methanol / 16 h / Heating

3.1: KOH / methanol; tetrahydrofuran / 1 h / 20 °C

3.2: H₂SO₄ / tetrahydrofuran / 1 h / 20 °C

4.1: 0.46 g / AcOH; NH₄OAc / 1 h / 100 °C

With potassium hydroxide; sodium hydroxide; ammonium acetate; acetic acid; diethylamine; In tetrahydrofuran; methanol; ethanol;
DOI:10.1021/jo050696k

Reference yield:

: 628308-82-7
3-((4-diethylaminomethyl)-phenyl)-1-(4-methoxyphenyl)-propenone

: 862201-40-9
diethyl-{4-[5-(4-methoxyphenyl)-1H-pyrrol-3-yl]benzyl}-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 86 percent / Et₂NH / methanol / 16 h / Heating

2.1: KOH / methanol; tetrahydrofuran / 1 h / 20 °C

2.2: H₂SO₄ / tetrahydrofuran / 1 h / 20 °C

3.1: 0.46 g / AcOH; NH₄OAc / 1 h / 100 °C

With potassium hydroxide; ammonium acetate; acetic acid; diethylamine; In tetrahydrofuran; methanol;
DOI:10.1021/jo050696k