4-O-(tert-butyldimethylsilyl)-11-oxo-13-deoxo-4'-demethylepipodophyllotoxin

Base Information

Chemical Name:4-O-(tert-butyldimethylsilyl)-11-oxo-13-deoxo-4'-demethylepipodophyllotoxin
CAS No.:845863-32-3
Molecular Formula:C₂₇H₃₄O₈Si
Molecular Weight:514.648
Hs Code.:

Synonyms:4-O-(tert-butyldimethylsilyl)-11-oxo-13-deoxo-4'-demethylepipodophyllotoxin

Suppliers and Price of 4-O-(tert-butyldimethylsilyl)-11-oxo-13-deoxo-4'-demethylepipodophyllotoxin

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Chemical Property of 4-O-(tert-butyldimethylsilyl)-11-oxo-13-deoxo-4'-demethylepipodophyllotoxin

Chemical Property:

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Technology Process of 4-O-(tert-butyldimethylsilyl)-11-oxo-13-deoxo-4'-demethylepipodophyllotoxin

There total 1 articles about 4-O-(tert-butyldimethylsilyl)-11-oxo-13-deoxo-4'-demethylepipodophyllotoxin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 153230-77-4
4,4'-bis(tert-butyldimethylsilyl)-4'-O-demethylepipodophyllol

: 6559-91-7
4'-demethylepipodophyllotoxin

: 845863-32-3
4-O-(tert-butyldimethylsilyl)-11-oxo-13-deoxo-4'-demethylepipodophyllotoxin

Guidance literature:: 4,4'-bis(tert-butyldimethylsilyl)-4'-O-demethylepipodophyllol; With molecular sieve; tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide; In dichloromethane; for 2h;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 0.333333h;
DOI:10.1021/jm0495733

Reference yield: 80.0%

: 845863-32-3
4-O-(tert-butyldimethylsilyl)-11-oxo-13-deoxo-4'-demethylepipodophyllotoxin

: 642409-76-5
11-oxo-13-deoxo-4'-demethylepipodophyllotoxin

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 23h;
DOI:10.1021/jm0495733

Reference yield:

: 845863-32-3
4-O-(tert-butyldimethylsilyl)-11-oxo-13-deoxo-4'-demethylepipodophyllotoxin

: (2-Amino-ethyl)-carbamic acid (5S,5aS,8aR,9R)-9-(4-hydroxy-3,5-dimethoxy-phenyl)-6-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / tetrabutylammonium fluoride / tetrahydrofuran / 23 h

2: 82 percent / Et₃N / CH₂Cl₂

3: 97 percent / pyridine / CH₂Cl₂ / 20 °C

4: 76 percent / Et₃N / CH₂Cl₂ / 0.5 h / 20 °C

5: 65 percent / H₂ / Pd/C / ethyl acetate / 3 h

With pyridine; tetrabutyl ammonium fluoride; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/jm0495733