(E)-3-(2-methyl-1-methyl-3H-quinaldinium iodide-6-yl)acrylic acid

Base Information

• Chemical Name: (E)-3-(2-methyl-1-methyl-3H-quinaldinium iodide-6-yl)acrylic acid
• CAS No.: 1403962-41-3
• Molecular Formula: C₁₄H₁₄NO₂*I
• Molecular Weight: 355.175
• Mol file: 1403962-41-3.mol

Synonyms:(E)-3-(2-methyl-1-methyl-3H-quinaldinium iodide-6-yl)acrylic acid

Chemical Property of (E)-3-(2-methyl-1-methyl-3H-quinaldinium iodide-6-yl)acrylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of (E)-3-(2-methyl-1-methyl-3H-quinaldinium iodide-6-yl)acrylic acid

There total 1 articles about (E)-3-(2-methyl-1-methyl-3H-quinaldinium iodide-6-yl)acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-Bromo-2-methyl-quinoline (877-42-9) → (E)-3-(2-methyl-1-methyl-3H-quinaldinium iodide-6-yl)acrylic acid (1403962-41-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: palladium diacetate; tris-(o-tolyl)phosphine; triethylamine / N,N-dimethyl-formamide / 18 h / 110 °C

2.1: lithium hydroxide / water; tetrahydrofuran / 12 h / Reflux

2.2: 20 °C / pH 2

3.1: sulfolane / 12 h / 110 °C

With palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; lithium hydroxide; In tetrahydrofuran; sulfolane; water; N,N-dimethyl-formamide;

DOI:10.1021/ol302481k

Reference yield: 29.0%

3-(5-(4-(bis(4-(hexyloxy)phenyl)amino)phenyl)-2,3-dihydrothieno[3,4-b][1,4]dioxin-7-yl)-4-hydroxycyclobut-3-ene-1,2-dione (1256844-75-3) + (E)-3-(2-methyl-1-methyl-3H-quinaldinium iodide-6-yl)acrylic acid (1403962-41-3) → (E)-3-[[[3-(5-(4-(bis(4-(hexyloxy)phenyl)amino)phenyl)-2,3-dihydrothieno[3,4-b][1,4]dioxin-7-yl)-2-hydroxy-4-oxo-2-cyclobuten-1-yl-diene]methyl]-1-methyl-3H-quinaldinium iodide-6-yl]acrylic acid

Guidance literature:

With butan-1-ol; In benzene; at 110 ℃; for 24h; Dean-Stark;

DOI:10.1021/ol302481k

upstream raw materials:

6-Bromo-2-methyl-quinoline