4-{2-[6-{[(2R)-2-isobutylpyrrolidin-1-yl]methyl}-2-oxo-3,5-bis[2-(trifluoromethoxy)phenyl]pyridin-1(2H)-yl]ethyl}benzoic acid monohydrochloride

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Chemical Name:4-{2-[6-{[(2R)-2-isobutylpyrrolidin-1-yl]methyl}-2-oxo-3,5-bis[2-(trifluoromethoxy)phenyl]pyridin-1(2H)-yl]ethyl}benzoic acid monohydrochloride
CAS No.:1201818-56-5
Molecular Formula:C₃₇H₃₆F₆N₂O₅*ClH
Molecular Weight:739.155
Hs Code.:

Synonyms:4-{2-[6-{[(2R)-2-isobutylpyrrolidin-1-yl]methyl}-2-oxo-3,5-bis[2-(trifluoromethoxy)phenyl]pyridin-1(2H)-yl]ethyl}benzoic acid monohydrochloride

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Chemical Property of 4-{2-[6-{[(2R)-2-isobutylpyrrolidin-1-yl]methyl}-2-oxo-3,5-bis[2-(trifluoromethoxy)phenyl]pyridin-1(2H)-yl]ethyl}benzoic acid monohydrochloride

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Technology Process of 4-{2-[6-{[(2R)-2-isobutylpyrrolidin-1-yl]methyl}-2-oxo-3,5-bis[2-(trifluoromethoxy)phenyl]pyridin-1(2H)-yl]ethyl}benzoic acid monohydrochloride

There total 6 articles about 4-{2-[6-{[(2R)-2-isobutylpyrrolidin-1-yl]methyl}-2-oxo-3,5-bis[2-(trifluoromethoxy)phenyl]pyridin-1(2H)-yl]ethyl}benzoic acid monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1201824-00-1
methyl 4-{2-[6-{[(2R)-2-isobutylpyrrolidin-1-yl]methyl}-2-oxo-3,5-bis[2-(trifluoromethoxy)phenyl]pyridin-1(2H)-yl]ethyl}benzoate

: 1201818-56-5
4-{2-[6-{[(2R)-2-isobutylpyrrolidin-1-yl]methyl}-2-oxo-3,5-bis[2-(trifluoromethoxy)phenyl]pyridin-1(2H)-yl]ethyl}benzoic acid monohydrochloride

Guidance literature:: methyl 4-{2-[6-{[(2R)-2-isobutylpyrrolidin-1-yl]methyl}-2-oxo-3,5-bis[2-(trifluoromethoxy)phenyl]pyridin-1(2H)-yl]ethyl}benzoate; With water; sodium hydroxide; In tetrahydrofuran; methanol; at 65 ℃; for 3h;

With hydrogenchloride; In ethyl acetate; at 20 ℃; Cooling with ice;

Reference yield:

: 1091599-76-6
methyl 4-[2-(5-bromo-3-chloro-6-methyl-2-oxopyridin-1(2H)-yl)ethyl]benzoate

: 1201818-56-5
4-{2-[6-{[(2R)-2-isobutylpyrrolidin-1-yl]methyl}-2-oxo-3,5-bis[2-(trifluoromethoxy)phenyl]pyridin-1(2H)-yl]ethyl}benzoic acid monohydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium phosphate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / palladium diacetate / ethyl acetate; toluene; water / 90 °C

2.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / Heating; Reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

4.1: sodium hydroxide; water / tetrahydrofuran; methanol / 3 h / 65 °C

4.2: 20 °C / Cooling with ice

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); water; potassium carbonate; sodium hydroxide; palladium diacetate; In tetrahydrofuran; methanol; tetrachloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1201823-01-9
methyl 4-[2-(3-chloro-6-methyl-2-oxopyridin-1(2H)-yl)ethyl]benzoate

: 1201818-56-5
4-{2-[6-{[(2R)-2-isobutylpyrrolidin-1-yl]methyl}-2-oxo-3,5-bis[2-(trifluoromethoxy)phenyl]pyridin-1(2H)-yl]ethyl}benzoic acid monohydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-Bromosuccinimide; acetic acid / water / 20 °C

2.1: potassium phosphate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / palladium diacetate / ethyl acetate; toluene; water / 90 °C

3.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / Heating; Reflux

4.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

5.1: sodium hydroxide; water / tetrahydrofuran; methanol / 3 h / 65 °C

5.2: 20 °C / Cooling with ice

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); water; potassium carbonate; acetic acid; sodium hydroxide; palladium diacetate; In tetrahydrofuran; methanol; tetrachloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;