3-(1-triphenylmethyl-1H-imidazol-4-yl)propyl 4-fluorobenzyl ether

Base Information

• Chemical Name: 3-(1-triphenylmethyl-1H-imidazol-4-yl)propyl 4-fluorobenzyl ether
• CAS No.: 183155-63-7
• Molecular Formula: C₃₂H₂₉FN₂O
• Molecular Weight: 476.593
• Mol file: 183155-63-7.mol

Synonyms:3-(1-triphenylmethyl-1H-imidazol-4-yl)propyl 4-fluorobenzyl ether

Chemical Property of 3-(1-triphenylmethyl-1H-imidazol-4-yl)propyl 4-fluorobenzyl ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(1-triphenylmethyl-1H-imidazol-4-yl)propyl 4-fluorobenzyl ether

There total 5 articles about 3-(1-triphenylmethyl-1H-imidazol-4-yl)propyl 4-fluorobenzyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

4-Fluorobenzyl bromide (459-46-1) + 3-(1-trityl-1H-imidazol-4-yl)propan-1-ol (152030-49-4) → 3-(1-triphenylmethyl-1H-imidazol-4-yl)propyl 4-fluorobenzyl ether (183155-63-7)

Guidance literature:

With 2,6-di-tert-butyl-pyridine; silver trifluoromethanesulfonate; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1002/1099-1344(200008)43:9<873::AID-JLCR371>3.0.CO;2-A

Reference yield:

sodium 3-(1-triphenylmethyl-1H-imidazol-4-yl)propanolate → 3-(1-triphenylmethyl-1H-imidazol-4-yl)propyl 4-fluorobenzyl ether (183155-63-7)

Guidance literature:

15-crown-5; In toluene; for 24h; Yield given; Heating;

DOI:10.1002/ardp.19963290802

Reference yield:

3-bromo-2-methoxy-tetrahydropyran (5324-21-0) → 3-(1-triphenylmethyl-1H-imidazol-4-yl)propyl 4-fluorobenzyl ether (183155-63-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 55 percent / 3 h / 165 °C

2: 57 percent / Et₃N / dimethylformamide / 12 h / 25 °C

3: 57 percent / AgOTf; 2,6-di-tert-butylpyridine / CH₂Cl₂ / 1 h / 20 °C

With 2,6-di-tert-butyl-pyridine; silver trifluoromethanesulfonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; 1: Condensation / 2: Substitution / 3: Substitution;

DOI:10.1002/1099-1344(200008)43:9<873::AID-JLCR371>3.0.CO;2-A

upstream raw materials:

4-Fluorobenzyl bromide

3-(1-trityl-1H-imidazol-4-yl)propan-1-ol

3,4-dihydro-2H-pyran

3-bromo-2-methoxy-tetrahydropyran