1-methyl-5-[4-(trifluoromethyl)phenyl]-4-[(trimethylsilyl)ethynyl]-1H-pyrazole

Base Information

Chemical Name:1-methyl-5-[4-(trifluoromethyl)phenyl]-4-[(trimethylsilyl)ethynyl]-1H-pyrazole
CAS No.:1356998-28-1
Molecular Formula:C₁₆H₁₇F₃N₂Si
Molecular Weight:322.405
Hs Code.:

Synonyms:1-methyl-5-[4-(trifluoromethyl)phenyl]-4-[(trimethylsilyl)ethynyl]-1H-pyrazole

Suppliers and Price of 1-methyl-5-[4-(trifluoromethyl)phenyl]-4-[(trimethylsilyl)ethynyl]-1H-pyrazole

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Chemical Property of 1-methyl-5-[4-(trifluoromethyl)phenyl]-4-[(trimethylsilyl)ethynyl]-1H-pyrazole

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Technology Process of 1-methyl-5-[4-(trifluoromethyl)phenyl]-4-[(trimethylsilyl)ethynyl]-1H-pyrazole

There total 2 articles about 1-methyl-5-[4-(trifluoromethyl)phenyl]-4-[(trimethylsilyl)ethynyl]-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 455-13-0
4-Iodobenzotrifluoride

: 1356998-28-1
1-methyl-5-[4-(trifluoromethyl)phenyl]-4-[(trimethylsilyl)ethynyl]-1H-pyrazole

Guidance literature:: Multi-step reaction with 3 steps

1: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / N,N-dimethyl-formamide; ethanol / 2 h / 75 °C / Inert atmosphere

2: Iodine monochloride; acetic acid; sodium acetate / 4 h / 20 °C

3: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triphenylphosphine / N,N-dimethyl-formamide / 4 h / 75 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium acetate; Iodine monochloride; potassium carbonate; acetic acid; triethylamine; triphenylphosphine; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1356997-25-5
1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazole

: 1356998-28-1
1-methyl-5-[4-(trifluoromethyl)phenyl]-4-[(trimethylsilyl)ethynyl]-1H-pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1: Iodine monochloride; acetic acid; sodium acetate / 4 h / 20 °C

2: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triphenylphosphine / N,N-dimethyl-formamide / 4 h / 75 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium acetate; Iodine monochloride; acetic acid; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide;