1-(12-benzyl-7,13-dimethoxy-6H,12H-5,12-diazaindeno[1,2-b]phenanthren-5-yl)-ethanone

Base Information

Chemical Name:1-(12-benzyl-7,13-dimethoxy-6H,12H-5,12-diazaindeno[1,2-b]phenanthren-5-yl)-ethanone
CAS No.:1375488-05-3
Molecular Formula:C₃₀H₂₆N₂O₃
Molecular Weight:462.548
Hs Code.:

Synonyms:1-(12-benzyl-7,13-dimethoxy-6H,12H-5,12-diazaindeno[1,2-b]phenanthren-5-yl)-ethanone

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Chemical Property of 1-(12-benzyl-7,13-dimethoxy-6H,12H-5,12-diazaindeno[1,2-b]phenanthren-5-yl)-ethanone

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Technology Process of 1-(12-benzyl-7,13-dimethoxy-6H,12H-5,12-diazaindeno[1,2-b]phenanthren-5-yl)-ethanone

There total 8 articles about 1-(12-benzyl-7,13-dimethoxy-6H,12H-5,12-diazaindeno[1,2-b]phenanthren-5-yl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1375488-04-2
N-[(9-benzyl-1,4-dimethoxy-9H-carbazol-3-yl)methyl]-N-(2-iodophenyl)acetamide

: 1375488-05-3
1-(12-benzyl-7,13-dimethoxy-6H,12H-5,12-diazaindeno[1,2-b]phenanthren-5-yl)-ethanone

Guidance literature:: With palladium diacetate; potassium carbonate; triphenylphosphine; In N,N-dimethyl-formamide; at 120 ℃; for 7h; Inert atmosphere;
DOI:10.1016/j.tetlet.2012.03.131

Reference yield:

: 1375487-97-0
4-hydroxy-9H-carbazole-3-carbaldehyde

: 1375488-05-3
1-(12-benzyl-7,13-dimethoxy-6H,12H-5,12-diazaindeno[1,2-b]phenanthren-5-yl)-ethanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C / Inert atmosphere

2.2: 1 h / 20 °C / Inert atmosphere

3.1: copper(l) iodide / methanol; N,N-dimethyl-formamide / 10 h / 120 °C / Inert atmosphere

4.1: toluene-4-sulfonic acid / tetrahydrofuran / 0.25 h / Reflux; Inert atmosphere

5.1: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

6.1: palladium diacetate; potassium carbonate; triphenylphosphine / N,N-dimethyl-formamide / 7 h / 120 °C / Inert atmosphere

With N-Bromosuccinimide; copper(l) iodide; palladium diacetate; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.tetlet.2012.03.131

Reference yield:

: 1375488-00-8
9-benzyl-(4-benzyloxy)-1-bromo-9H-carbazole-3-carbaldehyde

: 1375488-05-3
1-(12-benzyl-7,13-dimethoxy-6H,12H-5,12-diazaindeno[1,2-b]phenanthren-5-yl)-ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: copper(l) iodide / methanol; N,N-dimethyl-formamide / 10 h / 120 °C / Inert atmosphere

2: toluene-4-sulfonic acid / tetrahydrofuran / 0.25 h / Reflux; Inert atmosphere

3: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

4: palladium diacetate; potassium carbonate; triphenylphosphine / N,N-dimethyl-formamide / 7 h / 120 °C / Inert atmosphere

With copper(l) iodide; palladium diacetate; potassium carbonate; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2012.03.131