1H-Pyrrolo[2,3-b]pyridine, 5-bromo-3-iodo-1-[(4-methylphenyl)sulfonyl]-

Base Information

• Chemical Name: 1H-Pyrrolo[2,3-b]pyridine, 5-bromo-3-iodo-1-[(4-methylphenyl)sulfonyl]-
• CAS No.: 875639-15-9
• Molecular Formula: C14H10 Br I N2 O2 S
• Molecular Weight: 477.12
• Mol file: 875639-15-9.mol

Synonyms:5-Bromo-3-iodo-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridine

Chemical Property of 1H-Pyrrolo[2,3-b]pyridine, 5-bromo-3-iodo-1-[(4-methylphenyl)sulfonyl]-

Chemical Property:

• Vapor Pressure: 1.64E-12mmHg at 25°C
• Refractive Index: 1.743
• Boiling Point: 558.6°C at 760 mmHg
• Flash Point: 291.6°C
• PSA: 60.34000
• Density: 2g/cm³
• LogP: 5.02960

Purity/Quality:

97% ^*data from raw suppliers

5-Bromo-3-iodo-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrolo[2,3-b]pyridine, 5-bromo-3-iodo-1-[(4-methylphenyl)sulfonyl]-

There total 7 articles about 1H-Pyrrolo[2,3-b]pyridine, 5-bromo-3-iodo-1-[(4-methylphenyl)sulfonyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-iodo-5-bromo-1H-pyrrolo[2,3-b]-pyridine (757978-18-0) + p-toluenesulfonyl chloride (98-59-9) → 5-bromo-3-iodo-1-(4-methylbenzene-1-sulfonyl)-1H-pyrrolo[2,3-b]pyridine (875639-15-9)

Guidance literature:

3-iodo-5-bromo-1H-pyrrolo[2,3-b]-pyridine; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.5h;

p-toluenesulfonyl chloride; In N,N-dimethyl-formamide; mineral oil; for 2h;

Reference yield: 90.0%

3-iodo-5-bromo-1H-pyrrolo[2,3-b]-pyridine (757978-18-0) + sodium hydroxide (1310-73-2) → 5-bromo-3-iodo-1-(4-methylbenzene-1-sulfonyl)-1H-pyrrolo[2,3-b]pyridine (875639-15-9)

Guidance literature:

3-iodo-5-bromo-1H-pyrrolo[2,3-b]-pyridine; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.333333h;

sodium hydroxide; In tetrahydrofuran; mineral oil; at 0 ℃; for 1.5h;

DOI:10.1021/jm401094t

Reference yield: 54.0%

5-bromo-3-iodo-1H-pyrazolo[3,4-b]pyridine (875781-18-3) + p-toluenesulfonyl chloride (98-59-9) → 5-bromo-3-iodo-1-(4-methylbenzene-1-sulfonyl)-1H-pyrrolo[2,3-b]pyridine (875639-15-9)

Guidance literature:

5-bromo-3-iodo-1H-pyrazolo[3,4-b]pyridine; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃;

p-toluenesulfonyl chloride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 3h;

DOI:10.1021/acs.jmedchem.0c01265

upstream raw materials:

3-iodo-5-bromo-1H-pyrrolo[2,3-b]-pyridine

p-toluenesulfonyl chloride

5-bromo-1H-pyrrolo[2,3-b]pyridine

sodium hydroxide

Downstream raw materials:

2-(5-bromo-1-tosyl-1H-pyrrolo[2,3-b]pyridine-3-yl)thiazole

5-bromo-3-(2-methoxyphenyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine

C₂₀H₁₆BrN₃O₂S

5-bromo-3-(4-fluoro-phenyl)-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine

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