1-[2-(2,4,6-trimethyl-3-nitrophenylsulfonylamino)ethyl]-4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecane

Base Information

Chemical Name:1-[2-(2,4,6-trimethyl-3-nitrophenylsulfonylamino)ethyl]-4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecane
CAS No.:1370451-39-0
Molecular Formula:C₂₅H₄₀N₆O₁₀S
Molecular Weight:616.693
Hs Code.:

Synonyms:1-[2-(2,4,6-trimethyl-3-nitrophenylsulfonylamino)ethyl]-4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecane

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Chemical Property of 1-[2-(2,4,6-trimethyl-3-nitrophenylsulfonylamino)ethyl]-4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecane

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Technology Process of 1-[2-(2,4,6-trimethyl-3-nitrophenylsulfonylamino)ethyl]-4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecane

There total 5 articles about 1-[2-(2,4,6-trimethyl-3-nitrophenylsulfonylamino)ethyl]-4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1370451-48-1
C₁₁H₁₄N₂O₄S

: tris(tert-butyl) 2,2',2''-(1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate hydrobromide

: 1370451-39-0
1-[2-(2,4,6-trimethyl-3-nitrophenylsulfonylamino)ethyl]-4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecane

Guidance literature:: C₁₁H₁₄N₂O₄S; tris(tert-butyl) 2,2',2''-(1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate hydrobromide; With sodium carbonate; In acetonitrile; for 5h; Inert atmosphere; Reflux;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1016/j.bmcl.2012.02.071

Reference yield:

: 1370451-28-7
2-(2,4,6-trimethyl-3-nitrophenylsulfonylamino)ethanol

: 1370451-39-0
1-[2-(2,4,6-trimethyl-3-nitrophenylsulfonylamino)ethyl]-4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecane

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: potassium hydroxide / water; toluene / 0.5 h / 20 °C

3.1: sodium carbonate / acetonitrile / 5 h / Inert atmosphere; Reflux

3.2: 3 h / 20 °C

With sodium carbonate; triethylamine; potassium hydroxide; In dichloromethane; water; toluene; acetonitrile;
DOI:10.1016/j.bmcl.2012.02.071

Reference yield:

: 603-71-4,34505-32-3,82795-90-2
nitromesitylene

: 1370451-39-0
1-[2-(2,4,6-trimethyl-3-nitrophenylsulfonylamino)ethyl]-4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecane

Guidance literature:: Multi-step reaction with 5 steps

1.1: chlorosulfonic acid / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / -78 - 20 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

4.1: potassium hydroxide / water; toluene / 0.5 h / 20 °C

5.1: sodium carbonate / acetonitrile / 5 h / Inert atmosphere; Reflux

5.2: 3 h / 20 °C

With chlorosulfonic acid; sodium carbonate; triethylamine; potassium hydroxide; In dichloromethane; water; toluene; acetonitrile;
DOI:10.1016/j.bmcl.2012.02.071