N-[(7-cyano-2-naphthyl)methyl][4-(4-methyl-1,4-diazepan-1-yl)phenyl]sulfamide

Base Information

Chemical Name:N-[(7-cyano-2-naphthyl)methyl][4-(4-methyl-1,4-diazepan-1-yl)phenyl]sulfamide
CAS No.:220220-38-2
Molecular Formula:C₂₄H₂₇N₅O₂S
Molecular Weight:449.577
Hs Code.:

Synonyms:N-[(7-cyano-2-naphthyl)methyl][4-(4-methyl-1,4-diazepan-1-yl)phenyl]sulfamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[(7-cyano-2-naphthyl)methyl][4-(4-methyl-1,4-diazepan-1-yl)phenyl]sulfamide

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Technology Process of N-[(7-cyano-2-naphthyl)methyl][4-(4-methyl-1,4-diazepan-1-yl)phenyl]sulfamide

There total 6 articles about N-[(7-cyano-2-naphthyl)methyl][4-(4-methyl-1,4-diazepan-1-yl)phenyl]sulfamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4318-37-0
1-Methylhomopiperazine

: 220220-38-2
N-[(7-cyano-2-naphthyl)methyl][4-(4-methyl-1,4-diazepan-1-yl)phenyl]sulfamide

Guidance literature:: Multi-step reaction with 5 steps

1: 69 percent / K₂CO₃ / dimethylformamide / 17 h / 100 °C

2: H₂ / Pd/C / ethanol / 2 h / 20 °C

3: AcOH; NaB(OAc)3H / CH₂Cl₂ / 2 h / 20 °C

4: 75 percent / pyridine / 1,2-dichloro-ethane / 17 h / 20 °C

5: aq. HCl / CHCl₃; ethyl acetate / 6 h / 20 °C

With pyridine; hydrogenchloride; hydrogen; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; palladium on activated charcoal; In ethanol; dichloromethane; chloroform; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2004.07.046

Reference yield:

: 771584-75-9
tert-butyl ({[(7-cyano-2-naphthyl)methyl][4-(4-methyl-1,4-diazepan-1-yl)phenyl]amino}sulfonyl)carbamate

: 220220-38-2
N-[(7-cyano-2-naphthyl)methyl][4-(4-methyl-1,4-diazepan-1-yl)phenyl]sulfamide

Guidance literature:: With hydrogenchloride; In chloroform; ethyl acetate; at 20 ℃; for 6h;
DOI:10.1016/j.bmc.2004.07.046

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 220220-38-2
N-[(7-cyano-2-naphthyl)methyl][4-(4-methyl-1,4-diazepan-1-yl)phenyl]sulfamide

Guidance literature:: Multi-step reaction with 5 steps

1: 69 percent / K₂CO₃ / dimethylformamide / 17 h / 100 °C

2: H₂ / Pd/C / ethanol / 2 h / 20 °C

3: AcOH; NaB(OAc)3H / CH₂Cl₂ / 2 h / 20 °C

4: 75 percent / pyridine / 1,2-dichloro-ethane / 17 h / 20 °C

5: aq. HCl / CHCl₃; ethyl acetate / 6 h / 20 °C

With pyridine; hydrogenchloride; hydrogen; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; palladium on activated charcoal; In ethanol; dichloromethane; chloroform; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2004.07.046