Phosphoric acid (2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester (2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 1-methyl-2-oxo-propyl ester

Base Information

• Chemical Name: Phosphoric acid (2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester (2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 1-methyl-2-oxo-propyl ester
• CAS No.: 87471-47-4
• Molecular Formula: C₃₀H₃₆N₅O₁₃P
• Molecular Weight: 705.615

Synonyms:Phosphoric acid (2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester (2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 1-methyl-2-oxo-propyl ester

Chemical Property of Phosphoric acid (2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester (2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 1-methyl-2-oxo-propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phosphoric acid (2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester (2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 1-methyl-2-oxo-propyl ester

There total 3 articles about Phosphoric acid (2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester (2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 1-methyl-2-oxo-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C50H52N5O14P (87471-38-3) → Phosphoric acid (2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester (2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 1-methyl-2-oxo-propyl ester (87471-47-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 0.333333h;

DOI:10.1016/S0040-4020(01)91932-5

Reference yield:

N4-Benzoyl-5'-O-monomethoxytrityl-2'-deoxycytidine (60920-99-2) → Phosphoric acid (2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester (2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 1-methyl-2-oxo-propyl ester (87471-47-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) triethylamine 2.) triethylamine / 1.) at 20 degC for 2 h, dichloromethane 2.) at 0 degC for 15 h, at 20 degC for 2 h., DMF

2: 90 percent / trifluoroacetic acid / CH₂Cl₂ / 0.33 h / 0 °C

With triethylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/S0040-4020(01)91932-5

Reference yield:

thymidine (50-89-5,28854-96-8,3545-96-8,50-88-4) → Phosphoric acid (2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester (2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 1-methyl-2-oxo-propyl ester (87471-47-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) triethylamine 2.) triethylamine / 1.) at 20 degC for 2 h, dichloromethane 2.) at 0 degC for 15 h, at 20 degC for 2 h., DMF

2: 90 percent / trifluoroacetic acid / CH₂Cl₂ / 0.33 h / 0 °C

With triethylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/S0040-4020(01)91932-5

upstream raw materials:

C₅₀H₅₂N₅O₁₄P

N⁴-Benzoyl-5'-O-monomethoxytrityl-2'-deoxycytidine

thymidine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 87471-47-4 Phosphoric acid (2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester (2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 1-methyl-2-oxo-propyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send