DL-4-methylphenylglycine nitrile

Base Information

• Chemical Name: DL-4-methylphenylglycine nitrile
• CAS No.: 56464-69-8
• Molecular Formula: C₉H₁₀N₂
• Molecular Weight: 146.192

Synonyms:DL-4-methylphenylglycine nitrile

Chemical Property of DL-4-methylphenylglycine nitrile

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

amino(4-methylphenyl)acetonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DL-4-methylphenylglycine nitrile

There total 7 articles about DL-4-methylphenylglycine nitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-hydroxy-2-(4-methylphenyl)acetonitrile (4815-10-5) → DL-4-methylphenylglycine nitrile (56464-69-8)

Guidance literature:

With titanium(IV) isopropylate; ammonia; In methanol; at 40 ℃; for 18h;

DOI:10.1021/acs.orglett.9b03194

Reference yield: 91.0%

4-methyl-benzaldehyde (104-87-0) + 2-hydroxy-2-methylpropanenitrile (75-86-5) → DL-4-methylphenylglycine nitrile (56464-69-8)

Guidance literature:

4-methyl-benzaldehyde; With lithium hexamethyldisilazane; In tetrahydrofuran; at 25 ℃; for 4h;

2-hydroxy-2-methylpropanenitrile; In tetrahydrofuran; at 25 ℃; for 12h;

DOI:10.1081/SCC-200043270

Reference yield:

sodium cyanide (773837-37-9) + 4-methyl-benzaldehyde (104-87-0) → DL-4-methylphenylglycine nitrile (56464-69-8)

Guidance literature:

With ammonium chloride; In methanol; water; at 20 ℃; for 48h;

upstream raw materials:

2-(4-methylphenyl)-2-(trimethylsilyloxy)acetonitrile

2-hydroxy-2-(4-methylphenyl)acetonitrile

sodium cyanide

4-methyl-benzaldehyde

Downstream raw materials:

C₉H₇ClN₂

N-acetylamino-1-(4-methylphenyl)acetonitrile

2-amino-2-(4-methylphenyl)acetic acid

N,N'diacetyl-1-(4-methylphenyl)ethylenediamine

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