(S_S,2S,3S)-N-[4-chloro-2-(diphenylmethyleneamino)-4-ethyl-3-(p-toluenesulfinylamino)hexanoyl]pyrrolidine

Base Information

• Chemical Name: (S_S,2S,3S)-N-[4-chloro-2-(diphenylmethyleneamino)-4-ethyl-3-(p-toluenesulfinylamino)hexanoyl]pyrrolidine
• CAS No.: 1425458-25-8
• Molecular Formula: C₃₂H₃₈ClN₃O₂S
• Molecular Weight: 564.192

Synonyms:(S_S,2S,3S)-N-[4-chloro-2-(diphenylmethyleneamino)-4-ethyl-3-(p-toluenesulfinylamino)hexanoyl]pyrrolidine

Chemical Property of (S_S,2S,3S)-N-[4-chloro-2-(diphenylmethyleneamino)-4-ethyl-3-(p-toluenesulfinylamino)hexanoyl]pyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S_S,2S,3S)-N-[4-chloro-2-(diphenylmethyleneamino)-4-ethyl-3-(p-toluenesulfinylamino)hexanoyl]pyrrolidine

There total 3 articles about (S_S,2S,3S)-N-[4-chloro-2-(diphenylmethyleneamino)-4-ethyl-3-(p-toluenesulfinylamino)hexanoyl]pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

(SS)-N-(2-chloro-2-ethylbutylidene)-p-toluenesulfinamide + N-(diphenylmethylene)-2-oxo-2-(pyrrolidin-1-yl)ethanamine (147032-42-6) → (SS,2S,3S)-N-[4-chloro-2-(diphenylmethyleneamino)-4-ethyl-3-(p-toluenesulfinylamino)hexanoyl]pyrrolidine (1425458-25-8)

Guidance literature:

N-(diphenylmethylene)-2-oxo-2-(pyrrolidin-1-yl)ethanamine; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

(S_S)-N-(2-chloro-2-ethylbutylidene)-p-toluenesulfinamide; In tetrahydrofuran; at -78 ℃; for 0.25h; diastereoselective reaction; Inert atmosphere;

DOI:10.3762/bjoc.8.239

Reference yield:

(S)-p-toluenesulfinimide (188447-91-8) → (SS,2S,3S)-N-[4-chloro-2-(diphenylmethyleneamino)-4-ethyl-3-(p-toluenesulfinylamino)hexanoyl]pyrrolidine (1425458-25-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: titanium(IV) tetraethanolate / dichloromethane / 18 h / 20 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 0.25 h / -78 °C / Inert atmosphere

With titanium(IV) tetraethanolate; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;

DOI:10.3762/bjoc.8.239

Reference yield:

2-chloro-2-ethylbutyraldehyde (57240-62-7) → (SS,2S,3S)-N-[4-chloro-2-(diphenylmethyleneamino)-4-ethyl-3-(p-toluenesulfinylamino)hexanoyl]pyrrolidine (1425458-25-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: titanium(IV) tetraethanolate / dichloromethane / 18 h / 20 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 0.25 h / -78 °C / Inert atmosphere

With titanium(IV) tetraethanolate; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;

DOI:10.3762/bjoc.8.239

upstream raw materials:

N-(diphenylmethylene)-2-oxo-2-(pyrrolidin-1-yl)ethanamine

(S)-p-toluenesulfinimide

2-chloro-2-ethylbutyraldehyde

Downstream raw materials:

(S_S,2S,2'S)-N-{2-(diphenylmethyleneamino)-2-[3,3-diethyl-1-(p-toluenesulfinyl)aziridin-2-yl]acetyl}pyrrolidine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1425458-25-8 (S_S,2S,3S)-N-[4-chloro-2-(diphenylmethyleneamino)-4-ethyl-3-(p-toluenesulfinylamino)hexanoyl]pyrrolidine

Send

Send

Metric Ton KG G Pound L ML

Send

Send