(R)-ethyl 3-(N-benzyl-N-((R)-1-phenylethyl)amino)-4-phenylbutanoate

Base Information

• Chemical Name: (R)-ethyl 3-(N-benzyl-N-((R)-1-phenylethyl)amino)-4-phenylbutanoate
• CAS No.: 884318-80-3
• Molecular Formula: C₂₇H₃₁NO₂
• Molecular Weight: 401.549
• Mol file: 884318-80-3.mol

Synonyms:(R)-ethyl 3-(N-benzyl-N-((R)-1-phenylethyl)amino)-4-phenylbutanoate

Chemical Property of (R)-ethyl 3-(N-benzyl-N-((R)-1-phenylethyl)amino)-4-phenylbutanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-ethyl 3-(N-benzyl-N-((R)-1-phenylethyl)amino)-4-phenylbutanoate

There total 1 articles about (R)-ethyl 3-(N-benzyl-N-((R)-1-phenylethyl)amino)-4-phenylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

ethyl 3-benzylacrylate (54966-42-6,1466-22-4) + (R)-N-benzyl-1-phenylethylamine (38235-77-7) → (R)-ethyl 3-(N-benzyl-N-((R)-1-phenylethyl)amino)-4-phenylbutanoate (884318-80-3)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.666667h;

DOI:10.1016/j.tet.2005.12.030

Reference yield: 62.0%

(R)-ethyl 3-(N-benzyl-N-((R)-1-phenylethyl)amino)-4-phenylbutanoate (884318-80-3) → (R)-ethyl 3-(N-((R)-1-phenylethyl)amino)-4-phenylpentanoate (884318-82-5)

Guidance literature:

With ammonium cerium(IV) nitrate; water; In acetonitrile; at 20 ℃; for 1h;

DOI:10.1016/j.tet.2005.12.030

Reference yield:

(R)-ethyl 3-(N-benzyl-N-((R)-1-phenylethyl)amino)-4-phenylbutanoate (884318-80-3) → (2S,3R)-ethyl 3-benzyl-1-((R)-1-phenylethyl)aziridine-2-carboxylate

Guidance literature:

Multi-step reaction with 3 steps

1: 62 percent / ceric ammonium nitrate; H₂O / acetonitrile / 1 h / 20 °C

2: n-BuLi / tetrahydrofuran; hexane / 0.33 h / -78 °C

3: 48 percent / NBS / acetonitrile / 0.08 h / 20 °C

With N-Bromosuccinimide; n-butyllithium; ammonium cerium(IV) nitrate; water; In tetrahydrofuran; hexane; acetonitrile;

DOI:10.1016/j.tet.2005.12.030

upstream raw materials:

ethyl 3-benzylacrylate

(R)-N-benzyl-1-phenylethylamine

Downstream raw materials:

(R)-ethyl 3-(N-((R)-1-phenylethyl)amino)-4-phenylpentanoate

(2S,3R)-ethyl 4-phenyl-3-(N-((R)-1-phenylethyl)amino)-2-(phenylselanyl)butanoate

(2R,3R)-ethyl 4-phenyl-3-(N-((R)-1-phenylethyl)amino)-2-(phenylselanyl)butanoate

ethyl (2R,3R)-3-benzyl-1-[(R)-1-phenylethyl]aziridine-2-carboxylate