N-(3-(5-(chloromethyl)-1,2,4-oxadiazol-3-yl)-5-(imidazo[1,2-b]pyridazin-2-yl)phenyl)methanesulfonamide

Base Information

Chemical Name:N-(3-(5-(chloromethyl)-1,2,4-oxadiazol-3-yl)-5-(imidazo[1,2-b]pyridazin-2-yl)phenyl)methanesulfonamide
CAS No.:1149382-02-4
Molecular Formula:C₁₆H₁₃ClN₆O₃S
Molecular Weight:404.837
Hs Code.:

Synonyms:N-(3-(5-(chloromethyl)-1,2,4-oxadiazol-3-yl)-5-(imidazo[1,2-b]pyridazin-2-yl)phenyl)methanesulfonamide

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Chemical Property of N-(3-(5-(chloromethyl)-1,2,4-oxadiazol-3-yl)-5-(imidazo[1,2-b]pyridazin-2-yl)phenyl)methanesulfonamide

Chemical Property:

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Technology Process of N-(3-(5-(chloromethyl)-1,2,4-oxadiazol-3-yl)-5-(imidazo[1,2-b]pyridazin-2-yl)phenyl)methanesulfonamide

There total 10 articles about N-(3-(5-(chloromethyl)-1,2,4-oxadiazol-3-yl)-5-(imidazo[1,2-b]pyridazin-2-yl)phenyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₄H₁₄N₆O₃S

: 541-88-8
Chloroacetic anhydride

: 1149382-02-4
N-(3-(5-(chloromethyl)-1,2,4-oxadiazol-3-yl)-5-(imidazo[1,2-b]pyridazin-2-yl)phenyl)methanesulfonamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 9h; Heating / reflux;

Reference yield:

: 1149382-00-2
N-(3-cyano-5-(imidazo[1,2-b]pyridazin-2-yl)phenyl)methanesulfonamide

: 541-88-8
Chloroacetic anhydride

: 1149382-02-4
N-(3-(5-(chloromethyl)-1,2,4-oxadiazol-3-yl)-5-(imidazo[1,2-b]pyridazin-2-yl)phenyl)methanesulfonamide

Guidance literature:: N-(3-cyano-5-(imidazo[1,2-b]pyridazin-2-yl)phenyl)methanesulfonamide; With hydroxylamine hydrochloride; triethylamine; In ethanol; for 4h; Reflux;

Chloroacetic anhydride; With triethylamine; In tetrahydrofuran; at 20 ℃; for 9h; Reflux;

Reference yield:

: 199536-01-1
methyl 3-amino-5-cyanobenzoate

: 1149382-02-4
N-(3-(5-(chloromethyl)-1,2,4-oxadiazol-3-yl)-5-(imidazo[1,2-b]pyridazin-2-yl)phenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / dmap / dichloromethane / 1.5 h / Reflux

2.1: N,N`-dimethylethylenediamine / toluene / 2 h / 20 °C / Inert atmosphere; Cooling with ice

2.2: Inert atmosphere; Reflux

3.1: bromine / diethyl ether / 1.5 h

4.1: ethanol / 3.5 h / Reflux

5.1: palladium 10% on activated carbon / tetrahydrofuran / 6 h / 20 °C

6.1: hydroxylamine hydrochloride; triethylamine / ethanol / 4 h / Reflux

6.2: 9 h / 20 °C / Reflux

With pyridine; hydroxylamine hydrochloride; bromine; triethylamine; N,N`-dimethylethylenediamine; dmap; palladium 10% on activated carbon; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; toluene;