(cis)-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-3-methyl-6-(trifluoromethyl)-2H-1-benzazepin-2-one

Base Information

Chemical Name:(cis)-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-3-methyl-6-(trifluoromethyl)-2H-1-benzazepin-2-one
CAS No.:128510-83-8
Molecular Formula:C₁₉H₁₈F₃NO₂
Molecular Weight:349.353
Hs Code.:

Synonyms:(cis)-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-3-methyl-6-(trifluoromethyl)-2H-1-benzazepin-2-one

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Chemical Property of (cis)-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-3-methyl-6-(trifluoromethyl)-2H-1-benzazepin-2-one

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Technology Process of (cis)-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-3-methyl-6-(trifluoromethyl)-2H-1-benzazepin-2-one

There total 15 articles about (cis)-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-3-methyl-6-(trifluoromethyl)-2H-1-benzazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 1.0%

: 111605-18-6,119252-06-1,138573-55-4,138663-28-2
(3S,4R)-4-(4-Methoxy-phenyl)-3-methyl-2-oxo-6-trifluoromethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepine-3-carboxylic acid methyl ester

: 128510-83-8
(cis)-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-3-methyl-6-(trifluoromethyl)-2H-1-benzazepin-2-one

: 111605-19-7,128510-83-8,138573-73-6,138663-32-8
trans-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-3-methyl-6-(trifluoromethyl)-2H-1-benzazepin-2-one

Guidance literature:: With 4-amino-phenol; lithium bromide; In N,N-dimethyl-formamide; at 140 ℃; for 5h;
DOI:10.1021/jm00082a019

Reference yield: 1.0%

: 111605-18-6,119252-06-1,138573-55-4,138663-28-2
(3S,4R)-4-(4-Methoxy-phenyl)-3-methyl-2-oxo-6-trifluoromethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepine-3-carboxylic acid methyl ester

: 128510-83-8
(cis)-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-3-methyl-6-(trifluoromethyl)-2H-1-benzazepin-2-one

: 111605-19-7,128510-83-8,138573-73-6,138663-32-8
trans-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-3-methyl-6-(trifluoromethyl)-2H-1-benzazepin-2-one

Guidance literature:: With 4-amino-phenol; lithium bromide; In N,N-dimethyl-formamide; at 140 ℃; for 5h;
DOI:10.1021/jm00082a019

Reference yield:

: 138573-29-2
2-[1-(4-Methoxy-phenyl)-2-(2-nitro-6-trifluoromethyl-phenyl)-ethyl]-2-methyl-malonic acid dimethyl ester

: 128510-83-8
(cis)-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-3-methyl-6-(trifluoromethyl)-2H-1-benzazepin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / 10percent Pd/C / acetonitrile / 4 h / 2068.6 Torr

2: MeONa / methanol / 3 h / Heating

3: LiBr / dimethylformamide / 4 h / Heating

With hydrogen; sodium methylate; lithium bromide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00082a020