tert-butyl 2-{[(4-aminophenyl)methyl](2-{4,7-bis[2-(tert-butoxy)-2-oxoethyl]-1,4,7-triazonan-1-yl}ethyl)amino}acetate

Base Information

Chemical Name:tert-butyl 2-{[(4-aminophenyl)methyl](2-{4,7-bis[2-(tert-butoxy)-2-oxoethyl]-1,4,7-triazonan-1-yl}ethyl)amino}acetate
CAS No.:1258946-38-1
Molecular Formula:C₃₃H₅₇N₅O₆
Molecular Weight:619.845
Hs Code.:

Synonyms:tert-butyl 2-{[(4-aminophenyl)methyl](2-{4,7-bis[2-(tert-butoxy)-2-oxoethyl]-1,4,7-triazonan-1-yl}ethyl)amino}acetate

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Chemical Property of tert-butyl 2-{[(4-aminophenyl)methyl](2-{4,7-bis[2-(tert-butoxy)-2-oxoethyl]-1,4,7-triazonan-1-yl}ethyl)amino}acetate

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Technology Process of tert-butyl 2-{[(4-aminophenyl)methyl](2-{4,7-bis[2-(tert-butoxy)-2-oxoethyl]-1,4,7-triazonan-1-yl}ethyl)amino}acetate

There total 7 articles about tert-butyl 2-{[(4-aminophenyl)methyl](2-{4,7-bis[2-(tert-butoxy)-2-oxoethyl]-1,4,7-triazonan-1-yl}ethyl)amino}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1016237-79-8
t-butyl (4-tert-butoxycarbonylmethyl-7-{2-[tert-butoxycarbonylmethyl-(4-nitro-benzyl)-amino]ethyl}-[1,4,7]triazonan-1-yl)acetate

: 1258946-38-1
tert-butyl 2-{[(4-aminophenyl)methyl](2-{4,7-bis[2-(tert-butoxy)-2-oxoethyl]-1,4,7-triazonan-1-yl}ethyl)amino}acetate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 14h; under 1034.32 Torr; Inert atmosphere;
DOI:10.1016/j.bmcl.2015.01.008

Reference yield:

: 1016237-75-4
t-butyl [(2-hydroxy-ethyl)-(4-nitro-benzyl)-amino]acetate

: 1258946-38-1
tert-butyl 2-{[(4-aminophenyl)methyl](2-{4,7-bis[2-(tert-butoxy)-2-oxoethyl]-1,4,7-triazonan-1-yl}ethyl)amino}acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 2.17 h / -60 °C

1.2: 0.5 h / -60 °C

2.1: sodium tris(acetoxy)borohydride / dichloromethane / 18 h / 0 - 20 °C

3.1: hydrogen; palladium 10% on activated carbon / ethanol / 14 h / 20 °C / 1034.32 Torr / Inert atmosphere

With oxalyl dichloride; palladium 10% on activated carbon; hydrogen; sodium tris(acetoxy)borohydride; In ethanol; dichloromethane; dimethyl sulfoxide; 1.1: |Swern Oxidation;
DOI:10.1016/j.bmcl.2015.01.008

Reference yield:

: tert-butyl 2-({[4-(nitro)phenyl]methyl}(2-oxoethyl)amino)acetate

: 1258946-38-1
tert-butyl 2-{[(4-aminophenyl)methyl](2-{4,7-bis[2-(tert-butoxy)-2-oxoethyl]-1,4,7-triazonan-1-yl}ethyl)amino}acetate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride / dichloromethane / 18 h / 0 - 20 °C

2: hydrogen; palladium 10% on activated carbon / ethanol / 14 h / 20 °C / 1034.32 Torr / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; sodium tris(acetoxy)borohydride; In ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2015.01.008