2,8-Dimethylimidazo[1,2-a]pyridine-3-carboxylic acid

Base Information

• Chemical Name: 2,8-Dimethylimidazo[1,2-a]pyridine-3-carboxylic acid
• CAS No.: 874605-59-1
• Molecular Formula: C10H10 N2 O2
• Molecular Weight: 190.2
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID90371236
• Wikidata: Q82158516
• Mol file: 874605-59-1.mol

Synonyms:2,8-dimethylimidazo[1,2-a]pyridine-3-carboxylic acid;874605-59-1;2,8-Dimethylimidazo[1,2-a]pyridine-3-carboxylicacid;MFCD00269632;SCHEMBL1340395;2,8-Dimethyl-Imidazo[1,2-A]Pyridine-3-Carboxylic Acid;DTXSID90371236;Imidazo[1,2-a]pyridine-3-carboxylic acid, 2,8-dimethyl-;ZJB60559;STK692718;AKOS000345478;DC-0729;SY295256;BB 0219831;CS-0084382;FT-0680924;EN300-1197404;J-507547

Chemical Property of 2,8-Dimethylimidazo[1,2-a]pyridine-3-carboxylic acid

Chemical Property:

• Melting Point: 122-123°
• Refractive Index: 1.635
• PKA: -0.53±0.41(Predicted)
• PSA: 54.60000
• Density: 1.31g/cm³
• LogP: 1.64930
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 190.074227566
• Heavy Atom Count: 14
• Complexity: 244

Purity/Quality:

99%, ^*data from raw suppliers

2,8-Dimethylimidazo[1,2-a]pyridine-3-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=CN2C1=NC(=C2C(=O)O)C

Technology Process of 2,8-Dimethylimidazo[1,2-a]pyridine-3-carboxylic acid

There total 2 articles about 2,8-Dimethylimidazo[1,2-a]pyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methylpyridin-2-ylamine (1603-40-3) → 2,8-dimethylimidazo[1,2-a]pyridine-3-carboxylic acids (874605-59-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,2-dimethoxyethane / 48 h / Reflux; Inert atmosphere

2: lithium hydroxide / ethanol / Inert atmosphere

With lithium hydroxide; In 1,2-dimethoxyethane; ethanol;

DOI:10.1021/ml400088y

Reference yield:

ethyl 2,8-dimethylimidazo[1,2-a]pyridine-3-carboxylate (241146-66-7) → 2,8-dimethylimidazo[1,2-a]pyridine-3-carboxylic acids (874605-59-1)

Guidance literature:

With lithium hydroxide; In ethanol; Inert atmosphere;

DOI:10.1021/ml400088y

Reference yield: 76.0%

4-(4-fluorophenoxyl)benzylamine hydrochloride (568565-86-6) + 2,8-dimethylimidazo[1,2-a]pyridine-3-carboxylic acids (874605-59-1) → N-(4-(4-fluorophenoxy)benzyl)-2,8-dimethylimidazo[1,2-a]pyridine-3-carboxamide (1440650-79-2)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/ml400088y

upstream raw materials:

3-methylpyridin-2-ylamine

ethyl 2,8-dimethylimidazo[1,2-a]pyridine-3-carboxylate

Downstream raw materials:

N-(4-(4-fluorophenoxy)benzyl)-2,8-dimethylimidazo[1,2-a]pyridine-3-carboxamide

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