C₅₁H₇₅N₃O₇Si₂

Base Information

• Chemical Name: C₅₁H₇₅N₃O₇Si₂
• CAS No.: 155005-87-1
• Molecular Formula: C₅₁H₇₅N₃O₇Si₂
• Molecular Weight: 898.343
• Mol file: 155005-87-1.mol

Synonyms:C₅₁H₇₅N₃O₇Si₂

Chemical Property of C₅₁H₇₅N₃O₇Si₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₁H₇₅N₃O₇Si₂

There total 17 articles about C₅₁H₇₅N₃O₇Si₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

C51H75BrO7Si2 (155005-85-9) → C51H75N3O7Si2 (155005-87-1)

Guidance literature:

DOI:10.1021/ja00081a050

Reference yield:

C29H46O5 → C51H75N3O7Si2 (155005-87-1)

Guidance literature:

Multi-step reaction with 16 steps

1: 90 percent / DMAP, Et₃N / CH₂Cl₂ / 1.5 h / 0 °C

2: 1.) Py*HCl, (Cl₂CHCO)2O, 2.) Na₂CO₃ / 1.) xylene, 150-155 deg C, 0.5 h, 2.) acetone, H₂O, 25 deg C, 14 h

3: pyridine / 5 h / 0 °C

4: 1.) PhSeSePh, NaBH₄, 2.) mCPBA, Na₂CO₃ / 1.) EtOH, reflux, 1.5 h, 2.) THF, 25 deg C, 24 h

5: MeSOPh / CH₂Cl₂ / -78 °C

6: 94 percent / thiourea, NaHCO₃ / ethanol / 18 h / 70 °C

7: 85 percent / ClCH₂CO₂H, DEAD, PPh₃ / 18 h / 25 °C

8: 99 percent / AgNO₃ / dimethylformamide / 0.08 h / 25 °C

9: 1.) OsO₄, (S,S)-N,N-di<(mesitylene)methyl>-1,2-diphenyl-1,2-ethylenediamine, 2.) aq. NaHSO₃ / 1.) CH₂Cl₂, -100 deg C, 0.5 h, 2.) THF, reflux

10: 91 percent / NBS / tetrahydrofuran / 0.5 h / -78 °C

11: n-Bu₃SnH / 80 °C

12: imidazole / dimethylformamide / 1 h / 25 °C

13: aq. KHCO₃ / methanol / 3 h / Heating

14: Brown-Jones oxidation

15: 76 percent / PTAB / tetrahydrofuran / 0.25 h / 0 °C

16: 93 percent

With pyridine; 1H-imidazole; dmap; sodium tetrahydroborate; N-Bromosuccinimide; osmium(VIII) oxide; racemic methyl phenyl sulfoxide; PTAB; diphenyl diselenide; tri-n-butyl-tin hydride; pyridine hydrochloride; sodium hydrogencarbonate; sodium carbonate; potassium hydrogencarbonate; silver nitrate; sodium hydrogensulfite; dichloroacetic anhydride; (1S,2S)-1,2-diphenyl-N¹,N²-bis(mesitylmethyl)ethane-1,2-diamine; triethylamine; thiourea; chloroacetic acid; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja00081a050

Reference yield:

C31H48O6 → C51H75N3O7Si2 (155005-87-1)

Guidance literature:

Multi-step reaction with 15 steps

1: 1.) Py*HCl, (Cl₂CHCO)2O, 2.) Na₂CO₃ / 1.) xylene, 150-155 deg C, 0.5 h, 2.) acetone, H₂O, 25 deg C, 14 h

2: pyridine / 5 h / 0 °C

3: 1.) PhSeSePh, NaBH₄, 2.) mCPBA, Na₂CO₃ / 1.) EtOH, reflux, 1.5 h, 2.) THF, 25 deg C, 24 h

4: MeSOPh / CH₂Cl₂ / -78 °C

5: 94 percent / thiourea, NaHCO₃ / ethanol / 18 h / 70 °C

6: 85 percent / ClCH₂CO₂H, DEAD, PPh₃ / 18 h / 25 °C

7: 99 percent / AgNO₃ / dimethylformamide / 0.08 h / 25 °C

8: 1.) OsO₄, (S,S)-N,N-di<(mesitylene)methyl>-1,2-diphenyl-1,2-ethylenediamine, 2.) aq. NaHSO₃ / 1.) CH₂Cl₂, -100 deg C, 0.5 h, 2.) THF, reflux

9: 91 percent / NBS / tetrahydrofuran / 0.5 h / -78 °C

10: n-Bu₃SnH / 80 °C

11: imidazole / dimethylformamide / 1 h / 25 °C

12: aq. KHCO₃ / methanol / 3 h / Heating

13: Brown-Jones oxidation

14: 76 percent / PTAB / tetrahydrofuran / 0.25 h / 0 °C

15: 93 percent

With pyridine; 1H-imidazole; sodium tetrahydroborate; N-Bromosuccinimide; osmium(VIII) oxide; racemic methyl phenyl sulfoxide; PTAB; diphenyl diselenide; tri-n-butyl-tin hydride; pyridine hydrochloride; sodium hydrogencarbonate; sodium carbonate; potassium hydrogencarbonate; silver nitrate; sodium hydrogensulfite; dichloroacetic anhydride; (1S,2S)-1,2-diphenyl-N¹,N²-bis(mesitylmethyl)ethane-1,2-diamine; thiourea; chloroacetic acid; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja00081a050

upstream raw materials:

C₅₁H₇₅BrO₇Si₂

Acetic acid (2S,4aS,4bS,6R,6aS,6bS,9aS,10aS,10bR,12aS)-2-acetoxy-8-((R)-4-hydroxy-3-methyl-butyl)-4a,6a,7-trimethyl-2,3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12,12a-hexadecahydro-1H-9-oxa-pentaleno[2,1-a]phenanthren-6-yl ester

Acetic acid (2S,4aS,4bS,6R,6aS,6bS,9aS,10aS,10bR,12aS)-2-acetoxy-4a,6a,7-trimethyl-8-(3-methyl-but-3-enyl)-2,3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12,12a-hexadecahydro-1H-9-oxa-pentaleno[2,1-a]phenanthren-6-yl ester

Acetic acid (2S,4aS,4bS,6R,6aS,6bS,9aS,10aS,10bR,12aS)-2-acetoxy-4a,6a,7-trimethyl-8-[(R)-3-methyl-4-(toluene-4-sulfonyloxy)-butyl]-2,3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12,12a-hexadecahydro-1H-9-oxa-pentaleno[2,1-a]phenanthren-6-yl ester