(E)-1-[4-(2-Benzhydryloxy-ethyl)-piperazin-1-yl]-3-(4-hydroxy-phenyl)-propenone

Base Information

Chemical Name:(E)-1-[4-(2-Benzhydryloxy-ethyl)-piperazin-1-yl]-3-(4-hydroxy-phenyl)-propenone
CAS No.:1026635-75-5
Molecular Formula:C₂₈H₃₀N₂O₃
Molecular Weight:442.558
Hs Code.:

Synonyms:(E)-1-[4-(2-Benzhydryloxy-ethyl)-piperazin-1-yl]-3-(4-hydroxy-phenyl)-propenone

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Chemical Property of (E)-1-[4-(2-Benzhydryloxy-ethyl)-piperazin-1-yl]-3-(4-hydroxy-phenyl)-propenone

Chemical Property:

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Technology Process of (E)-1-[4-(2-Benzhydryloxy-ethyl)-piperazin-1-yl]-3-(4-hydroxy-phenyl)-propenone

There total 7 articles about (E)-1-[4-(2-Benzhydryloxy-ethyl)-piperazin-1-yl]-3-(4-hydroxy-phenyl)-propenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1026806-53-0
1-[4-(2-benzhydryloxy-ethyl)-piperazin-1-yl]-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propenone

: 1026635-75-5
(E)-1-[4-(2-Benzhydryloxy-ethyl)-piperazin-1-yl]-3-(4-hydroxy-phenyl)-propenone

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 0.333333h;
DOI:10.1021/jm990291q

Reference yield:

: 91-01-0
1,1-Diphenylmethanol

: 1026635-75-5
(E)-1-[4-(2-Benzhydryloxy-ethyl)-piperazin-1-yl]-3-(4-hydroxy-phenyl)-propenone

Guidance literature:: Multi-step reaction with 4 steps

1: H₂SO₄ / toluene / Heating

2: K₂CO₃ / toluene / 12 h / Heating

3: aq. NaHCO₃ / CHCl₃ / 0.17 h

4: tetrabutylammonium fluoride trihydrate / tetrahydrofuran / 0.33 h

With sulfuric acid; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran; chloroform; toluene; 1: Condensation / 2: Alkylation / 3: Acylation / 4: desilylation;
DOI:10.1021/jm990291q

Reference yield:

: 7400-08-0,50940-26-6
p-Coumaric Acid

: 1026635-75-5
(E)-1-[4-(2-Benzhydryloxy-ethyl)-piperazin-1-yl]-3-(4-hydroxy-phenyl)-propenone

Guidance literature:: Multi-step reaction with 4 steps

1: imidazole / dimethylformamide / 20 °C

2: oxalyl chloride; DMF / CH₂Cl₂ / 2 h / 0 - 20 °C

3: aq. NaHCO₃ / CHCl₃ / 0.17 h

4: tetrabutylammonium fluoride trihydrate / tetrahydrofuran / 0.33 h

With 1H-imidazole; oxalyl dichloride; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; chloroform; N,N-dimethyl-formamide; 1: silylation / 2: Chlorination / 3: Acylation / 4: desilylation;
DOI:10.1021/jm990291q