exo-cis-2,3-bis(tert-butyldimethylsilyloxymethyl)-7-oxabicyclo[2.2.1]hept-5-ene

Base Information

• Chemical Name: exo-cis-2,3-bis(tert-butyldimethylsilyloxymethyl)-7-oxabicyclo[2.2.1]hept-5-ene
• CAS No.: 130156-81-9
• Molecular Formula: C₂₀H₄₀O₃Si₂
• Molecular Weight: 384.707

Synonyms:exo-cis-2,3-bis(tert-butyldimethylsilyloxymethyl)-7-oxabicyclo[2.2.1]hept-5-ene

Chemical Property of exo-cis-2,3-bis(tert-butyldimethylsilyloxymethyl)-7-oxabicyclo[2.2.1]hept-5-ene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of exo-cis-2,3-bis(tert-butyldimethylsilyloxymethyl)-7-oxabicyclo[2.2.1]hept-5-ene

There total 1 articles about exo-cis-2,3-bis(tert-butyldimethylsilyloxymethyl)-7-oxabicyclo[2.2.1]hept-5-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

exo-3,6-epoxy-1,2,3,6-tetrahydrophthalic anhydride (6118-51-0) → exo-cis-2,3-bis(tert-butyldimethylsilyloxymethyl)-7-oxabicyclo[2.2.1]hept-5-ene (130156-81-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 24 h / -10 - 20 °C / Inert atmosphere

1.2: 16 h / 20 °C

2.1: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1002/adsc.201500971

Reference yield: 89.0%

exo-cis-2,3-bis(tert-butyldimethylsilyloxymethyl)-7-oxabicyclo[2.2.1]hept-5-ene (130156-81-9) → (1R,2R,3S,4R,5S)-2,3-Bis-(tert-butyl-dimethyl-silanyloxymethyl)-5-(dimethyl-phenyl-silanyl)-7-oxa-bicyclo[2.2.1]heptane (142634-39-7)

Guidance literature:

In tetrahydrofuran; at -40 ℃;

DOI:10.1021/jo00041a003

Reference yield: 85.0%

tert.-butyl lithium (594-19-4) + 5,6-Bis-(tert-butyl-dimethyl-silanyloxymethyl)-7-oxa-bicyclo[2.2.1]hept-2-ene (130156-81-9) → (1S,2R,5R,6S)-2-tert-Butyl-5,6-bis-(tert-butyl-dimethyl-silanyloxymethyl)-cyclohex-3-enol (130156-87-5)

Guidance literature:

With CuCN; In tetrahydrofuran; 0 deg C -> r. t.;

DOI:10.1016/S0040-4039(00)89036-X

upstream raw materials:

exo-3,6-epoxy-1,2,3,6-tetrahydrophthalic anhydride

Downstream raw materials:

(1R,2R,5S,6R)-2-Butyl-5,6-bis-(tert-butyl-dimethyl-silanyloxymethyl)-cyclohex-3-enol

(1S,2R,5R,6S)-2-tert-Butyl-5,6-bis-(tert-butyl-dimethyl-silanyloxymethyl)-cyclohex-3-enol

(1S,2S,5R,6S)-2-sec-Butyl-5,6-bis-(tert-butyl-dimethyl-silanyloxymethyl)-cyclohex-3-enol

(1R,5S,6R)-5,6-Bis-(tert-butyl-dimethyl-silanyloxymethyl)-cyclohex-3-enol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

✦Write with AI

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 130156-81-9 exo-cis-2,3-bis(tert-butyldimethylsilyloxymethyl)-7-oxabicyclo[2.2.1]hept-5-ene

Send

Send

Metric Ton KG G Pound L ML

Send

Send