(22S,23R,25R)-3β-methoxy-23-tert-butyldimethylsilyloxy-26-(2-nitrophenylselenyl)-5α-furostan

Base Information

Chemical Name:(22S,23R,25R)-3β-methoxy-23-tert-butyldimethylsilyloxy-26-(2-nitrophenylselenyl)-5α-furostan
CAS No.:425622-44-2
Molecular Formula:C₄₀H₆₅NO₅SeSi
Molecular Weight:747.005
Hs Code.:

Synonyms:(22S,23R,25R)-3β-methoxy-23-tert-butyldimethylsilyloxy-26-(2-nitrophenylselenyl)-5α-furostan

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Chemical Property of (22S,23R,25R)-3β-methoxy-23-tert-butyldimethylsilyloxy-26-(2-nitrophenylselenyl)-5α-furostan

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Technology Process of (22S,23R,25R)-3β-methoxy-23-tert-butyldimethylsilyloxy-26-(2-nitrophenylselenyl)-5α-furostan

There total 7 articles about (22S,23R,25R)-3β-methoxy-23-tert-butyldimethylsilyloxy-26-(2-nitrophenylselenyl)-5α-furostan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 51694-22-5
ortho-nitrophenyl selenocyanate

: 425622-30-6
(22S,23R,25R)-3β-methoxy-23-tert-butyldimethylsilyloxy-5α-furostan-26-ol

: 425622-44-2
(22S,23R,25R)-3β-methoxy-23-tert-butyldimethylsilyloxy-26-(2-nitrophenylselenyl)-5α-furostan

Guidance literature:: With tributylphosphine; In tetrahydrofuran; at 20 ℃; for 0.5h;
DOI:10.1021/ol025580e

Reference yield:

: 213528-59-7
3-methoxy-23-oxotigogenin

: 425622-44-2
(22S,23R,25R)-3β-methoxy-23-tert-butyldimethylsilyloxy-26-(2-nitrophenylselenyl)-5α-furostan

Guidance literature:: Multi-step reaction with 6 steps

1: NaBH₄ / ethanol / 1 h / 20 °C

2: Ph₂SiH₂; TiCl₄ / CH₂Cl₂ / -20 °C

3: 95 percent / pyridine / CH₂Cl₂ / 14 h / 20 °C

4: 81 percent / Et₃N / CH₂Cl₂ / 3 h / 20 °C

5: 92 percent / KOH / methanol / 24 h / 50 °C

6: 98.5 percent / n-Bu₃P / tetrahydrofuran / 0.5 h / 20 °C

With pyridine; potassium hydroxide; sodium tetrahydroborate; tributylphosphine; diphenylsilane; titanium tetrachloride; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1016/j.tet.2005.01.077

Reference yield:

: 213528-50-8
(22S,23R,25R)-3-methoxy-5-furostan-23,26-diol

: 425622-44-2
(22S,23R,25R)-3β-methoxy-23-tert-butyldimethylsilyloxy-26-(2-nitrophenylselenyl)-5α-furostan

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / pyridine / CH₂Cl₂ / 14 h / 20 °C

2: 81 percent / Et₃N / CH₂Cl₂ / 3 h / 20 °C

3: 92 percent / KOH / methanol / 24 h / 50 °C

4: 98.5 percent / n-Bu₃P / tetrahydrofuran / 0.5 h / 20 °C

With pyridine; potassium hydroxide; tributylphosphine; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.tet.2005.01.077