<1R-(1α,2β,5α)>-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl 2-hydroxy-3-nitropropanoate

Base Information

Chemical Name:<1R-(1α,2β,5α)>-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl 2-hydroxy-3-nitropropanoate
CAS No.:185515-94-0
Molecular Formula:C₁₉H₂₇NO₅
Molecular Weight:349.427
Hs Code.:

Synonyms:<1R-(1α,2β,5α)>-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl 2-hydroxy-3-nitropropanoate

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Chemical Property of <1R-(1α,2β,5α)>-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl 2-hydroxy-3-nitropropanoate

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Technology Process of <1R-(1α,2β,5α)>-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl 2-hydroxy-3-nitropropanoate

There total 4 articles about <1R-(1α,2β,5α)>-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl 2-hydroxy-3-nitropropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 75-52-5
nitromethane

: 84312-20-9
(1R,3R,4S)-8-phenylmenthyl glyoxylate

: 185515-94-0
<1R-(1α,2β,5α)>-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl 2-hydroxy-3-nitropropanoate

Guidance literature:: With aluminum oxide; 1.) 0 deg C, 0.5 h, 2.) r.t., 3 h;
DOI:10.1039/CC9960002543

Reference yield:

: 65253-04-5
(-)-8-phenylmenthol

: 185515-94-0
<1R-(1α,2β,5α)>-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl 2-hydroxy-3-nitropropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / Et₃N, DMAP / CH₂Cl₂ / 0.08 h / 0 °C

2: 100 percent / aq. NaIO₄, OsO₄ / dioxane / 2 h

3: 91 percent / neutral alumina / 1.) 0 deg C, 0.5 h, 2.) r.t., 3 h

With dmap; aluminum oxide; sodium periodate; osmium(VIII) oxide; triethylamine; In 1,4-dioxane; dichloromethane;
DOI:10.1039/CC9960002543

Reference yield:

: 72526-00-2
(-)-8-phenylmenthyl acrylate

: 185515-94-0
<1R-(1α,2β,5α)>-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl 2-hydroxy-3-nitropropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / aq. NaIO₄, OsO₄ / dioxane / 2 h

2: 91 percent / neutral alumina / 1.) 0 deg C, 0.5 h, 2.) r.t., 3 h

With aluminum oxide; sodium periodate; osmium(VIII) oxide; In 1,4-dioxane;
DOI:10.1039/CC9960002543