EUPERGIT(R) C SPHERES

Base Information

• Chemical Name: EUPERGIT(R) C SPHERES
• CAS No.: 93356-75-3
• Molecular Weight: 0
• Mol file: 93356-75-3.mol

Synonyms:Eupergite C

Chemical Property of EUPERGIT(R) C SPHERES

Chemical Property:

• Storage Temp.: −20°C

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• General Description: EUPERGIT(R) C SPHERES, also known as Eupergite C, are polymer beads used as a support matrix for enzyme immobilization, such as penicillinacylase, to facilitate selective and efficient biocatalytic reactions, including the synthesis of aspartame by cleaving specific protecting groups under controlled pH conditions.

Refernces

IMMOBILIZED PENICILLINACYLASE: APPLICATION TO THE SYNTHESIS OF THE DIPEPTIDE ASPARTAME

10.1016/S0040-4039(00)84751-6

This research explores the application of immobilized penicillinacylase in the synthesis of the dipeptide sweetener aspartame. The purpose is to find a more selective and efficient method to replace the formyl group in the traditional synthesis route with a nitrogen protecting group that can be removed enzymatically. The researchers used penicillinacylase immobilized on Eupergit C beads to catalyze the conversion of N-phenacetyl aspartame into aspartame and phenylacetic acid at pH 7.5. The results showed that the enzyme selectively cleaved the phenacetyl group, and the rate of hydrolysis depended on the substituents at the α-carboxyl group of aspartic acid and the absolute configuration of aspartic acid.